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Vol. 27 No. 3 (2015): Vol 27 Issue 3

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Green Synthesis of 2-Benzoyl-4-quinazolinones

https://doi.org/10.14233/ajchem.2015.18677
Zhijie Li
Institute of Green Catalysis and Synthesis, College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, P.R. China
Yamei Pu
Institute of Green Catalysis and Synthesis, College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, P.R. China
Dezhi Qiu
Institute of Green Catalysis and Synthesis, College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, P.R. China
Xiaoping Zhang
Institute of Green Catalysis and Synthesis, College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, P.R. China
Qingle Zeng
Institute of Green Catalysis and Synthesis, College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, P.R. China

Corresponding Author(s) : Qingle Zeng

qinglezeng@hotmail.com

Asian Journal of Chemistry, Vol. 27 No. 3 (2015): Vol 27 Issue 3

Abstract

A catalyst-free synthesis of 2-benzoyl-4-quinazolinones is described here. Anthranilamides and a-haloacetophenones were used as the starting reagents. The effects of molar ratio of reactants, catalyst, solvent, base, temperature and time on the reaction were investigated and then the optimal reaction conditions were achieved. All of the substrates examined under the optimized conditions gave high yields. Compared to traditional synthesis method of 2-benzoyl-4-quinazolinones, this method has several advantages, such as no catalyst, cost saving and environmentally benign process.

Keywords

Catalyst-free 2-Benzoyl-4-quinazolinones Anthranilamides α-Haloacetophenones
Li, Z., Pu, Y., Qiu, D., Zhang, X., & Zeng, Q. (2015). Green Synthesis of 2-Benzoyl-4-quinazolinones. Asian Journal of Chemistry, 27(3), 1157–1159. https://doi.org/10.14233/ajchem.2015.18677
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