Synthesis and Antibacterial Activity of Copper(I) Complexes with Bisbenzoylthiourea

Meng-Meng Zhao; Xiu-Yan Dong; Gang Li; Xiao-Qin Yang

doi:10.14233/ajchem.2014.15897

Issue

Vol. 26 No. 1 (2014): Vol 26 Issue 1

Issue Published : December 26, 2013

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Antibacterial Activity of Copper(I) Complexes with Bisbenzoylthiourea

https://doi.org/10.14233/ajchem.2014.15897

Meng-Meng Zhao

School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, P.R. China

Xiu-Yan Dong

School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, P.R. China

Gang Li

School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, P.R. China

Xiao-Qin Yang

School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, P.R. China

Corresponding Author(s) : Xiu-Yan Dong

dxy568@163.com

Asian Journal of Chemistry, Vol. 26 No. 1 (2014): Vol 26 Issue 1
Article Published : December 27, 2013

Abstract

Two copper(I) complexes, [Cu(L)]ClO₄ (1) and [Cu(L)Cl]·C₂H₅OH (2), have been synthesized by the reaction of copper(II) perchlorate hexahydrate and copper(II) chloride dihydrate with N,N'-(1,2-dimethylene)bisbenzoylthiourea (L), respectively and characterized by elemental analyses as well as IR spectra and TG-DTA analyses. Antibacterial activity assays exhibit MIC₅₀ values of the two copper(I) complexes comparable to standard drugs for both Gram-positive and Gram-negative bacteria, both of them show stronger antibacterial activity.

Keywords

Bisbenzoylthiourea Complex Synthesis Antibacterial activity

Zhao, M.-M., Dong, X.-Y., Li, G., & Yang, X.-Q. (2013). Synthesis and Antibacterial Activity of Copper(I) Complexes with Bisbenzoylthiourea. Asian Journal of Chemistry, 26(1), 277–279. https://doi.org/10.14233/ajchem.2014.15897

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References

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References

P. Gómez-Saiz, J. García-Tojal, M. Maestro, J. Mahía, L. Lezama and T. Rojo, Eur. J. Inorg. Chem., 2003, 2123 (2003); doi:10.1002/ejic.200200571.

D. Kovala-Demertzi, A. Domopoulou, M. Demertzis, C.P. Raptopoulou and A. Terzis, Polyhedron, 13, 1917 (1994); doi:10.1016/0277-5387(94)80015-4.

M.B. Ferrari, G. Fava, C. Pelizzi and P. Tarasconi, J. Chem. Soc., Dalton Trans., 2153 (1992); doi:10.1039/dt9920002153.

I.C. Mendes, J.P. Moreira, N.L. Speziali, A.S. Mangrich, J.A. Takahashi and H. Beraldo, J. Braz. Chem. Soc., 17, 1571 (2006); doi:10.1590/S0103-50532006000800013.

Z.Y. Yang, Y. Wang and Y. Wang, Bioorg. Med. Chem. Lett., 17, 2096 (2007); doi:10.1016/j.bmcl.2006.10.049.

D.X. West, J.K. Swearingen, J. Valdés-Martínez, S. Hernández-Ortega, A.K. El-Sawaf, F. van Meurs, A. Castiñeiras, I. Garcia and E. Bermejo, Polyhedron, 18, 2919 (1999); doi:10.1016/S0277-5387(99)00210-7.

P. Tarasconi, S. Capacchi, G. Pelosi, M. Cornia, R. Albertini, A. Bonati, P.P. Dall’Aglio, P. Lunghi and S. Pinelli, Bioorg. Med. Org. Chem, 8, 157 (2000); doi:10.1016/S0968-0896(99)00260-6.

A. Kumar, Usha and S. Chandra, Synth. React. Inorg. Met. Org. Chem., 23, 671 (1993); doi:10.1080/15533179308016665.

L.J. Ackerman, P.E. Fanwick, M.A. Green, E. John, W.E. Running, J.K. Swearingen, J.W. Webb and D.X. West, Polyhedron, 18, 2759 (1999); doi:10.1016/S0277-5387(99)00173-4.

S. Teoh, S. Ang, H. Fun and C. Ong, J. Organomet. Chem., 580, 17 (1999); doi:10.1016/S0022-328X(98)01099-7.

E. Bermejo, R. Carballo, A. Castineiras, R. Dominguez, C. Maichle-Mössmer, J. Strähle and D.X. West, Polyhedron, 18, 3695 (1999); doi:10.1016/S0277-5387(99)00309-5.

P.N. Yadav, M.A. Demertzis, D. Kovala-Demertzi, S. Skoulika and D.X. West, Inorg. Chim. Acta, 349, 30 (2003); doi:10.1016/S0020-1693(03)00087-2.

K. Nomiya, K. Sekino, M. Ishikawa, A. Honda, M. Yokoyama, N.C. Kasuga, H. Yokoyama, S. Nakano and K. Onodera, J. Inorg. Biochem., 98, 601 (2004); doi:10.1016/j.jinorgbio.2004.01.011.

E. Guillon, A. Mohamadou, I. Déchamps-olivier and J. Barbier, Polyhedron, 15, 947 (1996); doi:10.1016/0277-5387(95)00305-6.

E. Guillon, I. Déchamps-olivier and J. Barbier, Polyhedron, 17, 3255 (1998); doi:10.1016/S0277-5387(98)00098-9.

L. Xian, T.B. Wei and Y.M. Zhang, J. Coord. Chem., 57, 453 (2004); doi:10.1080/00958970410001671147.

L.Q. Chai, Y.J. Ding, X.Q. Yang, H.B. Yan and W.K. Dong, Acta Crystallogr., E64, o1407 (2008).

W.K. Dong, X.Q. Yang, L.-Q. Chai, Y.-Q. Tian and J.-H. Feng, Phosphorus Sulfur and Silicon, 183, 1181 (2008); doi:10.1080/10426500701610952.

W.K. Dong, Y.X. Sun, S.J. Xing, Y. Wang and X.H. Gao, Z. Naturforsch, 67, 197 (2012); doi:10.5560/ZNB.2012.67b0197.

W.K. Dong, J.F. Tong, Y.X. Sun, S.S. Gong and L. Li, Synth. React. Inorg. Met. Org. Chem., 41, 155 (2011).

M. Kaspady, V.K. Narayanaswamy, M. Raju and G.K. Rao, Lett. Drug Des. Discov., 6, 21 (2009); doi:10.2174/157018009787158481.

W.J. Geary, Coord. Chem. Rev., 7, 81 (1971); doi:10.1016/S0010-8545(00)80009-0.

U. Bierbach, T.W. Hambley, J.D. Roberts and N. Farrell, Inorg. Chem., 35, 4865 (1996); doi:10.1021/ic960314g.

Issue

Vol. 26 No. 1 (2014): Vol 26 Issue 1

Synthesis and Antibacterial Activity of Copper(I) Complexes with Bisbenzoylthiourea

Corresponding Author(s) : Xiu-Yan Dong

Abstract

Keywords

Full Article

Download Citation

References

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