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Vol. 26 No. 1 (2014): Vol 26 Issue 1

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A New Dibenzocyclooctadiene Lignan from Stems of Schisandra lancifolia and its Bioactivities

https://doi.org/10.14233/ajchem.2014.15706
Yin-Ke Li
Collge of Resource and Environment, Yuxi Normal University, Yuxi 653100, P.R. China; Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Xian-Xue Wu
Collge of Resource and Environment, Yuxi Normal University, Yuxi 653100, P.R. China
Ming Li
Collge of Resource and Environment, Yuxi Normal University, Yuxi 653100, P.R. China
Gang Du
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Qiu-Fen Hu
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Xue-Mei Gao
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Corresponding Author(s) : Xue-Mei Gao

gao_xuemei@hotmail.com

Asian Journal of Chemistry, Vol. 26 No. 1 (2014): Vol 26 Issue 1

Abstract

A new dibenzocyclooctadiene lignan, lanciphenol A (1) was isolated from the stems of Schisandra lancifolia. The structure of 1 was elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compound 1 was evaluated for its anti HIV activity and cytotoxicity. It showed anti HIV-1 activity with therapeutic index value of 64.8 and cytotoxicity against NB4, A549 and MCF7 cell with IC50 values of 6.8, 7.5 and 8.4 μM, respectively.

Keywords

Dibenzocyclooctadiene lignan Schisandra lancifolia Anti HIV activity Cytotoxicity
Li, Y.-K., Wu, X.-X., Li, M., Du, G., Hu, Q.-F., & Gao, X.-M. (2013). A New Dibenzocyclooctadiene Lignan from Stems of Schisandra lancifolia and its Bioactivities. Asian Journal of Chemistry, 26(1), 224–226. https://doi.org/10.14233/ajchem.2014.15706
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