Issue

Vol. 26 No. 1 (2014): Vol 26 Issue 1

Copyright (c) 2014 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Potential Hepatoprotective Effect of Solanum xanthocarpum Against CCl4 Induced Hepatotoxicity in Albino Rats

https://doi.org/10.14233/ajchem.2014.15755
B. Dheeba
Department of Chemistry and Biosciences, Srinivasa Ramanujan Centre, SASTRA University, Kumbakonam-612 001, India
P. Sampathkumar
Department of Chemistry and Biosciences, Srinivasa Ramanujan Centre, SASTRA University, Kumbakonam-612 001, India
S. Vijay
Department of Chemistry and Biosciences, Srinivasa Ramanujan Centre, SASTRA University, Kumbakonam-612 001, India
K. Kannan
Department of Mathematics, Srinivasa Ramanujan Centre, SASTRA University, Kumbakonam-612 001, India
M. Kannan
Department of Microbiology, VHNSN College, Virudhunagar-626 001, India

Corresponding Author(s) : B. Dheeba

deepabaskaran76@gmail.com

Asian Journal of Chemistry, Vol. 26 No. 1 (2014): Vol 26 Issue 1

Abstract

The objective of current study is to assess the hepatoprotective effect of the ethanolic extract of Solanum xanthocarpum fruit in rat liver injured with carbon tetrachloride. The damage of the liver was studied in the experimental animals by assessing total protein, total bilirubin, cholesterol, serum glutamate oxaloacetate transaminase (SGOT), triglycerides, lactate dehydrogenase (LDH) and serum glutamate pyruvate transaminase (SGPT), in serum. The effect of co-administration of ethanolic extract of fruits of Solanum xanthocarpum (200 mg/Kg) on the above parameters was investigated. Hepatic damage was demonstrated with high levels of all parameters in serum of experimental animals which received carbon tetrachloride. The antioxidant assay of plant extract was proved against hydrogen peroxide and phospho molybdate assay. It is concluded that the fruits of Solanum xanthocarpum are rich in antioxidant and acts as a hepatoprotective agent and attenuates the hepatotoxic effect of carbon tetrachloride.

Keywords

Carbon tetrachloride Hepatic damage Solanum xanthocarpum
Dheeba, B., Sampathkumar, P., Vijay, S., Kannan, K., & Kannan, M. (2013). Potential Hepatoprotective Effect of Solanum xanthocarpum Against CCl4 Induced Hepatotoxicity in Albino Rats. Asian Journal of Chemistry, 26(1), 230–232. https://doi.org/10.14233/ajchem.2014.15755
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. P.L. Wolf, Indian J. Clin. Biochem., 14, 59 (1999); doi:10.1007/BF02869152.
  2. N. Mascolo, R. Sharma, S.C. Jain and F. Capasso, J. Ethnopharmacol., 22, 211 (2001): doi: 10.1016/0378-8741(88)90129-8.
  3. M. Parola, G. Leonarduzzi, F. Biasi, M. Albano, E. Biocca, G. Poli and U. Dianzani, Hepatology, 16, 1014 (1992); doi:10.1002/hep.1840160426.
  4. M.G. Rajesh and M.S. Latha, Indian J. Physiol. Pharmacol., 45, 481 (2001).
  5. Anonymous The wealth of India-Raw materials. Rh-So, CSIR, New Delhi, 4, 393 (1989).
  6. K.R. Kiritikar and B.D. Basu, Ann. Intern. Med., 104, 826 (1994).
  7. V.J. Ram and A. Goel, Curr. Med. Chem., 6, 217 (1999).
  8. B. Dheeba, E. Vaishnavi, P. Sampathkumar and M. Kannan, Biosci. Biotechnol. Res. Asia, 9 (June 1), 309 (2012).
  9. S. Alattin, B. Sahin, H. Agus, M. Bayav, H. Sevim and A. Semiz, J. Biol. Sci., 1, 29 (2007).
  10. M. Gupta, U.K. Mazumder, V. Thamilselvan, L. Manikandan, G.P. Senthilkumar, R. Suresh and B.K. Kakoyyi, Indian J. Pharmacol. Ther., 6, 5 (2007).
  11. M. Oktay, I.l. Gülçin and Ö.I. Küfrevioglu, LWT-Food Sci. Technol., 36, 263 (2003);doi: 10.1016/S0023-6438(02)00226-8.
  12. G.K. Jayaprakasha, B.S. Jena, P.S. Negi and K.K. Sakairah, Naturofrosch., 57c, 828 (2002).
  13. M. Kannan, A.J.A.R. Singh, T.T.A. Kumar, P. Jegatheswari and S. Subburayalu, Afr. J. Microbiol Res., 1, 88 (2007).
  14. B. Dheeba, P. Sampath kumar and M. Kannan, J. Pharm. Res., 5, 2469 (2012).
  15. O.H. Lowry, N.J. Rosebrough, A.L. Farr and R.J. Randell, J. Biol. Chem., 193, 265 (1951).
  16. M. Gupta, U.K. Mazumder, V. Thamilselvan, L. Manikandan, G.P. Senthilkumar, R. Suresh and B.K. Kakoyyi, Indian J. Pharmacol. Ther., 6, 5 (2007).
  17. E. Van Hendle and D.B. Zilversmith, J. Lab. Clin. Med., 50:152 (1957).
  18. S. Reitman and A.S. Frankel, Am. J. Clin. Pathol., 28, 53 (1957).
  19. M.K. Abdel-Rahman and A.A. Abd El-Megeid, World J. Chem., 1, 41 (2006).
  20. C.K. Kokate, R. Lakshmiah and M. Ramasatri, J. Nutr. Diet., 6, 200 (1995).
  21. M.W. Brooks and J.M. Clark, Pest. Biochem. Physiol., 28, 127 (1987); doi: 10.1016/0048-3575(87)90121-0.
  22. M. Donaldson, Nutr. J., 3, 19 (2004); doi:10.1186/1475-2891-3-19.
  23. M.R. Venukumar and M.S. Latha, Indian J. Pharmacol., 34, 269 (2002).
  24. A. Williams and R. Burk, Semin. Liver Dis., 10, 279 (1990); doi:10.1055/s-2008-1040483.
  25. L.-P. Yuan, F.-H. Chen, L. Ling, P.-F. Dou, H. Bo, M.-M. Zhong and L.-J. Xia, J. Ethnopharmacol., 116, 539 (2008); doi:10.1016/j.jep.2008.01.010.
  26. Y. Wu, L. Yang, F. Wang, X. Wu, C. Zhou, S. Shi, J. Mo and Y. Zhao, Food Chem. Toxicol., 45, 1349 (2007); doi:10.1016/j.fct.2007.01.011.
  27. C.K. Roy, J.V. Kamath and A.M. Asad, Indian J. Exp. Biol., 44, 305 (2006).
  28. Y. Jyothi, J.V. Kamath and M. Asad, Pak. J. Pharm. Sci., 19, 129 (2006).
  29. A.K. Gupta, C. Havagiray, S.K. Dass and N. Misra, J. Pharmacology Toxicol, 1, 82 (2006); doi:10.3923/jpt.2006.82.88.
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 0