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Vol. 26 No. 3 (2014): Vol 26 Issue 3

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Synthesis of Diethyl 5-Ethyl-2,3-Pyridinedicarboxylate

https://doi.org/10.14233/ajchem.2014.16235
Chunsheng Cheng
Technical Development Department, Shenyang Sciencreat Chemicals Co., LTD. Shenyang, Liaoning, P.R. China
Xiaohua Ma
Technical Development Department, Shenyang Sciencreat Chemicals Co., LTD. Shenyang, Liaoning, P.R. China
Zhenyun Wei
Technical Development Department, Shenyang Sciencreat Chemicals Co., LTD. Shenyang, Liaoning, P.R. China

Corresponding Author(s) : Chunsheng Cheng

chengchunsheng@sinochem.com ; tomorrow88166@163.com

Asian Journal of Chemistry, Vol. 26 No. 3 (2014): Vol 26 Issue 3

Abstract

Diethyl 5-ethyl-2,3-pyridinedicarboxylate was synthesized using ammonium acetate as the nitrogen source. The optimum process conditions were obtained by exploring the reaction mechanism and researching the effects of reactant ratio, reaction temperature and solvent amount on the yield from all sides. Diethyl 5-ethyl-2,3-pyridinedicarboxylate yield was 98 % analysis by HPLC and the overall yield 96.8 % calculated by 2-chloro-3-oxo-succinic acid diethyl ester. The optimum process has the advantages of available initial material, simple waste-water treatment and environmental friendliness which are more applicable for industrial production.

Keywords

Diethyl 5-ethyl-2 3-pyridinedicarboxylate Ammonium acetate Synthetic methods Reaction mechanisms Solvent effects
Cheng, C., Ma, X., & Wei, Z. (2014). Synthesis of Diethyl 5-Ethyl-2,3-Pyridinedicarboxylate. Asian Journal of Chemistry, 26(3), 918–920. https://doi.org/10.14233/ajchem.2014.16235
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