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One-Step Synthesis of 2-Thiazolidinone
Corresponding Author(s) : Li Hong Shen
Asian Journal of Chemistry,
Vol. 26 No. 3 (2014): Vol 26 Issue 3
Abstract
An efficient and direct access to thiazolidinone is developed. 2-Thiazolidinone is synthesized by urea and 2-aminoethylmercaptan hydrochloride and this one-step process proceeds with good yields, under mild conditions. The structure of the compound was confirmed by IR, 1H NMR, MS and the product purity was 98 % by HPLC.
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- R. Ottana, R. Maccari, M.L. Barreca, G. Bruno, A. Rotondo, A. Rossi, G. Chiricosta, R. Di Paola, L. Sautebin, S. Cuzzocrea and M.G. Vigorita, Bioorg. Med. Chem., 13, 4243 (2005);doi:10.1016/j.bmc.2005.04.058.
- P. Vicini, A. Geronikaki, K. Anastasia, M. Incerti and F. Zani, Bioorg. Med. Chem., 14, 3859 (2006);doi:10.1016/j.bmc.2006.01.043.
- R. Ottana, S. Carotti, R. Maccari, I. Landini, G. Chiricosta, B. Caciagli, M.G. Vigorita and E. Mini, Bioorg. Med. Chem. Lett., 15, 3930 (2005);doi:10.1016/j.bmcl.2005.05.093.
- P.C. Lv, C.F. Zhou, J. Chen, P.G. Liu, K.R. Wang, W.J. Mao, H.Q. Li, Y. Yang, J. Xiong and H.L. Zhu, Bioorg. Med. Chem., 18, 314 (2010);doi:10.1016/j.bmc.2009.10.051.
- M. Yagisawa, M. Kitano and Y. Morimoto, EP 0387028,1990-09-12.
- Kawamatsu Yutaka Kogyo K.K., JP 58177983, 1983-10-18.
- M. Yagisawa, M. Kitano and Y. Morimoto, EP 0387028A2, 1990-09-12.
- J.C. Crawhall and D.F. Elliott, J. Chem. Soc., 3094 (1952);doi:10.1039/JR9520003094.
- J.G. Michels and G. Gever, J. Am. Chem. Soc., 78, 5349 (1956);doi:10.1021/ja01601a052.
References
R. Ottana, R. Maccari, M.L. Barreca, G. Bruno, A. Rotondo, A. Rossi, G. Chiricosta, R. Di Paola, L. Sautebin, S. Cuzzocrea and M.G. Vigorita, Bioorg. Med. Chem., 13, 4243 (2005);doi:10.1016/j.bmc.2005.04.058.
P. Vicini, A. Geronikaki, K. Anastasia, M. Incerti and F. Zani, Bioorg. Med. Chem., 14, 3859 (2006);doi:10.1016/j.bmc.2006.01.043.
R. Ottana, S. Carotti, R. Maccari, I. Landini, G. Chiricosta, B. Caciagli, M.G. Vigorita and E. Mini, Bioorg. Med. Chem. Lett., 15, 3930 (2005);doi:10.1016/j.bmcl.2005.05.093.
P.C. Lv, C.F. Zhou, J. Chen, P.G. Liu, K.R. Wang, W.J. Mao, H.Q. Li, Y. Yang, J. Xiong and H.L. Zhu, Bioorg. Med. Chem., 18, 314 (2010);doi:10.1016/j.bmc.2009.10.051.
M. Yagisawa, M. Kitano and Y. Morimoto, EP 0387028,1990-09-12.
Kawamatsu Yutaka Kogyo K.K., JP 58177983, 1983-10-18.
M. Yagisawa, M. Kitano and Y. Morimoto, EP 0387028A2, 1990-09-12.
J.C. Crawhall and D.F. Elliott, J. Chem. Soc., 3094 (1952);doi:10.1039/JR9520003094.
J.G. Michels and G. Gever, J. Am. Chem. Soc., 78, 5349 (1956);doi:10.1021/ja01601a052.