Copyright (c) 2014 AJC
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Microdialysis Coupled with Capillary Electrophoresis Method for Continuous Monitoring of Free Tramadol in Rabbit Blood
Corresponding Author(s) : Li Wang
Asian Journal of Chemistry,
Vol. 26 No. 4 (2014): Vol 26 Issue 4
Abstract
The new analytical method for the determination of protein-free tramadol in rabbit blood has been developed based on microdialysis-capillary electrophoresis method. Microdialysis probe was implanted into the ear vein of the rabbits. Separation and detection were carried out on a Beckman P/ACE 5000 equipped with UV-absorbance detector using a filter of 214 nm. This assay was successfully applied to a pharmacokinetic study involving intravenous administration of a single dose of tramadol hydrochloride to rabbits.
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B.N. Patel, N. Sharma, M. Sanyal and P.S. Shrivastav, J. Pharm. Biomed. Anal., 49, 354 (2009); doi:10.1016/j.jpba.2008.10.030.
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M.D. Rockville, Food and Drug Administration, Guidance for Industry: Bioanalytical Method Validation, US Department of Health and Human Services, FDA, Center for Drug Evaluation and Research (2001).