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Vol. 26 No. 2 (2014): Vol 26 Issue 2

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Simultaneous Determination and Pharmacokinetics of Five Furocoumarins in Rat Plasma After Oral Administration of Radix Angelicae dahuricae Extract by High Performance Liquid Chromatography

https://doi.org/10.14233/ajchem.2014.15434
Yan Meng1
1Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, P.R. China 2Department of Clinical Pharmacy, The First Hospital of Shijiazhuang, Shijiazhuang 050011, P.R. China 3Department of Pharmacy, The First Hospital of Hebei Medical University, Shijiazhuang 050031, P.R. China 4Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, P.R. China *Corresponding author: Tel/Fax: +86 311 86266419; E-mail: zhanglantong@263.net †These authors contributed equally to this work.
Xuguang Zheng1
1Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, P.R. China 2Department of Clinical Pharmacy, The First Hospital of Shijiazhuang, Shijiazhuang 050011, P.R. China 3Department of Pharmacy, The First Hospital of Hebei Medical University, Shijiazhuang 050031, P.R. China 4Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, P.R. China *Corresponding author: Tel/Fax: +86 311 86266419; E-mail: zhanglantong@263.net †These authors contributed equally to this work.
Xiaohong Cui4
1Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, P.R. China 2Department of Clinical Pharmacy, The First Hospital of Shijiazhuang, Shijiazhuang 050011, P.R. China 3Department of Pharmacy, The First Hospital of Hebei Medical University, Shijiazhuang 050031, P.R. China 4Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, P.R. China *Corresponding author: Tel/Fax: +86 311 86266419; E-mail: zhanglantong@263.net †These authors contributed equally to this work.
Ning Sheng1
1Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, P.R. China 2Department of Clinical Pharmacy, The First Hospital of Shijiazhuang, Shijiazhuang 050011, P.R. China 3Department of Pharmacy, The First Hospital of Hebei Medical University, Shijiazhuang 050031, P.R. China 4Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, P.R. China *Corresponding author: Tel/Fax: +86 311 86266419; E-mail: zhanglantong@263.net †These authors contributed equally to this work.
Qiao Wang1
1Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, P.R. China 2Department of Clinical Pharmacy, The First Hospital of Shijiazhuang, Shijiazhuang 050011, P.R. China 3Department of Pharmacy, The First Hospital of Hebei Medical University, Shijiazhuang 050031, P.R. China 4Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, P.R. China *Corresponding author: Tel/Fax: +86 311 86266419; E-mail: zhanglantong@263.net †These authors contributed equally to this work.
Chunying Wang1
1Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, P.R. China 2Department of Clinical Pharmacy, The First Hospital of Shijiazhuang, Shijiazhuang 050011, P.R. China 3Department of Pharmacy, The First Hospital of Hebei Medical University, Shijiazhuang 050031, P.R. China 4Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, P.R. China *Corresponding author: Tel/Fax: +86 311 86266419; E-mail: zhanglantong@263.net †These authors contributed equally to this work.
Lantong Zhang1
1Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, P.R. China 2Department of Clinical Pharmacy, The First Hospital of Shijiazhuang, Shijiazhuang 050011, P.R. China 3Department of Pharmacy, The First Hospital of Hebei Medical University, Shijiazhuang 050031, P.R. China 4Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, P.R. China *Corresponding author: Tel/Fax: +86 311 86266419; E-mail: zhanglantong@263.net †These authors contributed equally to this work.

Asian Journal of Chemistry, Vol. 26 No. 2 (2014): Vol 26 Issue 2

Abstract

Radix Angelicae dahuricae, with coumarins as its main bioactive compounds, has been widely used for antihistamine, antibacterial, spasmolysis, promote lipolysis and chronic venous insufficiency. Simultaneous determination and pharmacokinetics of coumarin compounds in rat plasma is necessary. A rapid, reliable and sensitive method for the simultaneous determination of 5 furocoumarins i.e., psoralen, bergapten, imperatorin, cnidilin and isoimperatorin in rat plasma was developed using high-performance liquid chromatographic. The established method could be easily applied to the determination in vivo and pharmacokinetic studies of five coumarin compounds in rat plasma after oral administration of Radix Angelicae Dahuricae extract.

Keywords

Radix Angelicae dahuricae Coumarins HPLC-DAD Pharmacokinetics.
Meng1, Y., Zheng1, X., Cui4, X., Sheng1, N., Wang1, Q., Wang1, C., & Zhang1, L. (2014). Simultaneous Determination and Pharmacokinetics of Five Furocoumarins in Rat Plasma After Oral Administration of Radix Angelicae dahuricae Extract by High Performance Liquid Chromatography. Asian Journal of Chemistry, 26(2), 431–436. https://doi.org/10.14233/ajchem.2014.15434
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