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Vol. 31 No. 11 (2019): Vol 31 Issue 11

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Cytotoxic and Antibacterial Activity of Selected Medicinal Plants used in South African Traditional Medicine

https://doi.org/10.14233/ajchem.2019.22240
M.A. Makhafola
Department of Biology, Sefako Makgatho Health Sciences University, P.O. Box 139, Medunsa, Pretoria 0204, South Africa
https://orcid.org/0000-0001-7853-1328
L. Middleton
Department of Biology, Sefako Makgatho Health Sciences University, P.O. Box 139, Medunsa, Pretoria 0204, South Africa
https://orcid.org/0000-0002-5595-9142
M.T. Olivier
Department of Chemistry, Sefako Makgatho Health Sciences University, P.O. Box 235, Medunsa, Pretoria 0204, South Africa
https://orcid.org/0000-0003-0147-6361
O.O. Olaokun
Department of Biology, Sefako Makgatho Health Sciences University, P.O. Box 139, Medunsa, Pretoria 0204, South Africa
https://orcid.org/0000-0002-8004-3187

Corresponding Author(s) : O.O. Olaokun

Olivier.mutendela@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 11 (2019): Vol 31 Issue 11

Abstract

Five plants were investigated for their antibacterial and cytotoxicity activities, namely: Lantana rugosa, Lippia javanica, Lippia wilmsii, Hilliardiella elaeagnoides and Withania somnifera. Four organisms and liver cells were used to evaluate the efficacy and the safety of the extracts from these plants. All the extracts showed antibacterial activity with the MIC ranging from 0.04 ± 0.04 mg/mL to 11.46 ± 9.66 mg/mL. The acetonic extract of L. javanica exhibited the highest antibacterial activity with MIC value of 0.04 ± 0.04 mg/mL against P. aeruginosa and 0.28 ± 0.35 mg/mL against S. aureus. Aqueous and acetonic extracts of L. wilmsii (LC50 > 1000 μg/mL) and the hexane extract of L. javanica (LC50 > 1000 μg/mL) were the least cytotoxic. While acetonic extract of L. javanica (0.01 ± 0.64 μg/mL) and hexane extract of L. wilmsii (0.03 ± 0.31 μg/mL) were the most cytotoxic.

Keywords

Antibacterial activity Cytotoxicity Lantana rugosa Lippia javanica Lippia wilmsii Hilliardiella elaeagnoides Withania somnifera
Makhafola, M., Middleton, L., Olivier, M., & Olaokun, O. (2019). Cytotoxic and Antibacterial Activity of Selected Medicinal Plants used in South African Traditional Medicine. Asian Journal of Chemistry, 31(11), 2623–2627. https://doi.org/10.14233/ajchem.2019.22240
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