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Vol. 31 No. 11 (2019): Vol 31 Issue 11

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A Newfangled Synthesis of Integrase Inhibitor Drug Substance Raltegravir Potassium

https://doi.org/10.14233/ajchem.2019.22246
S. Venkat Rao
S.M.S. Pharmaceuticals Ltd., R&D Center (DSIR approved), Gagillapur (V), Rangareddy-500047, India
Vamsi Krishna Potluri
S.M.S. Pharmaceuticals Ltd., R&D Center (DSIR approved), Gagillapur (V), Rangareddy-500047, India
Ramesh Babu Potluri
S.M.S. Pharmaceuticals Ltd., R&D Center (DSIR approved), Gagillapur (V), Rangareddy-500047, India

Corresponding Author(s) : S. Venkat Rao

venkat@smspharma.com; svr.org@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 11 (2019): Vol 31 Issue 11

Abstract

Raltegravir sodium synthesis was achieved from its one of the key starting materials with retro synthetic approach, in which without using its critical starting material chemically known as 5-methyl-1,3,4-oxadiazole-2-carbonyl chloride and which is more unstable during the synthesis of raltegravir potassium. Almost all the existed literatures commonly using this starting material in its synthesis even it is having a stability issue and hence to achieve a stable and economically viable synthesis. The current research describes a new route of synthesis by constructing an oxadiazole ring in a retro synthetic manner.

Keywords

Synthesis 5-methyl-1,3,4-oxadiazole-2-carbonyl chloride Raltegravir potassium
Rao, S. V., Potluri, V. K., & Potluri, R. B. (2019). A Newfangled Synthesis of Integrase Inhibitor Drug Substance Raltegravir Potassium. Asian Journal of Chemistry, 31(11), 2618–2622. https://doi.org/10.14233/ajchem.2019.22246
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