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Vol. 31 No. 11 (2019): Vol 31 Issue 11

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Synthesis, Molecular Docking, Cytotoxicity and Antioxidant Activity Evaluation of Isoindoline-1,3-dione Derivatives

https://doi.org/10.14233/ajchem.2019.22185
Palanichamy Santhosh Kumar
Department of Chemistry, Karunya Institute of Technology and Science, Coimbatore-641114, India
Kuruba Bharath Kumar
School of Chemistry, Bharathidasan University, Tiruchirapalli-620024, India
Asir Obadiah
Department of Chemistry, Karunya Institute of Technology and Science, Coimbatore-641114, India
Suluvoy Jagadish Kumar
Department of Biotechnology, Karunya Institute of Technology and Science, Coimbatore-641114, India
Raman Mohanapriya
Department of Bioinformatics, Karunya Institute of Technology and Science, Coimbatore-641114, India
Arulappan Durairaj
Department of Chemistry, Karunya Institute of Technology and Science, Coimbatore-641114, India
Subramanian Ramanathan
Department of Chemistry, Karunya Institute of Technology and Science, Coimbatore-641114, India
Samuel Vasanthkumar
Department of Chemistry, Karunya Institute of Technology and Science, Coimbatore-641114, India

Corresponding Author(s) : Samuel Vasanthkumar

vasanthakumar@karunya.edu; santhoshchem2@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 11 (2019): Vol 31 Issue 11

Abstract

A variety of amines have been employed to functionalize isobenzofuran-1,3-dione to obtain isoindoline-1,3-dione derivatives in the base free conditions. All the synthesized compounds are screened for their bioactivity through molecular docking, cytotoxicity (against HeLa) and antioxidant activity. ABTS and DPPH are employed to assess the antioxidant activity. Among the synthesized isoindoline-1,3-dione derivatives (3a-k), compound 3e has showed the best antioxidant activity and also exhibited better binding energy when docked with caspase-3 protein. Cytotoxicity of the synthesized compounds was studied against cervical cancer cell line (HeLa) and compound 3e has displayed better activity than other isoindoline derivatives.

Keywords

Isobenzofuran-1,3-dione Isoindoline-1,3-dione Molecular docking Cytotoxicity HeLa cell lines Antioxidant activity
Kumar, P. S., Kumar, K. B., Obadiah, A., Kumar, S. J., Mohanapriya, R., Durairaj, A., … Vasanthkumar, S. (2019). Synthesis, Molecular Docking, Cytotoxicity and Antioxidant Activity Evaluation of Isoindoline-1,3-dione Derivatives. Asian Journal of Chemistry, 31(11), 2548–2556. https://doi.org/10.14233/ajchem.2019.22185
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