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Determination of Half-life of Dissolution Process of Oxaliplatin in DMSO
Corresponding Author(s) : J.L. Suo
Asian Journal of Chemistry,
Vol. 26 No. 7 (2014): Vol 26 Issue 7
Abstract
The enthalpies of dissolution for oxaliplatin in dimethyl sulfoxide were measured using a RD496-CK2000 calve microcalorimeter at 309.65 K under atmospheric pressure. Differential enthalpies and molar enthalpies were determined for oxaliplatin in dimethyl sulfoxide, then the relationship of the heat effect of each process with the amount of the substance was setted up. On the basis of the dynamics equation, the process of dissolution is a pseudo first order reaction was indicated. Meanwhile, the half-life period t1/2 = 59.32 min, the molar enthalpy DsolHm = 14.996 kJ mol-1, the molar gigs free energy DsolGm = 97.93 kJ mol-1, the molar entropy is DsolSm = -267.81 J mol-1 K-1 were calculated. The result not only provides a simple method for the detemination of the half-life for drugs, but also offer a theoretical reference for the clinical application of oxaliplatin
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References
Y. Kidani and K. Inagaki, cis-Platinum(II) complex of trans-l-1,2- diaminocyclohexane, US Patent 4169846 (1979).
J. Capdevila, E. Elez, S. Peralta, T. Macarulla, F.J. Ramos and J. Tabernero, Expert Rev. Anticancer Ther., 8, 1223 (2008); doi:10.1586/14737140.8.8.1223.
N. Sawabu, Nippon Shokakibyo Gakkai Zasshi, 100, 645 (2003).
J. Trédaniel, C. Becht, M. Bekradda, H. De Cremoux, J. Alexandre, F. Chomy, S. Szyldergemajn, Y. Yataghene and S. Culine, Lung Cancer, 63, 259 (2009); doi:10.1016/j.lungcan.2008.05.028.
A. Gunnlaugsson, H. Anderson, E. Fernebro, E. Kjellén, P. Byström, Å. Berglund, M. Ekelund, L. Påhlman, T. Holm, B. Glimelius and A. Johnsson, Eur. J. Cancer, 45, 807 (2009); doi:10.1016/j.ejca.2008.11.017.
Z. Wang, J. Zhou, J. Fan, S.-J. Qiu, Y. Yu, X.-W. Huang, J. Sun, C.-J. Tan and Z. Dai, Expert Opin. Investig. Drugs, 18, 1595 (2009); doi:10.1517/13543780903292626.
W.L. Lin, D.G. Li, Q. Chen, H.M. Lu, X.M. Ma and P.L. Sun, World Chin. J. Digestol., 11, 1535 (2003).
M. Galanski, A. Yasemi, M.A. Jakupec, N. Grafv. Keyserlingk and B.K. Keppler, Monatsh. Chem., 136, 693 (2005); doi:10.1007/s00706-004-0241-3.
R.L. Montgomery, R.A. Melaugh, C.-C. Lau, G.H. Meier, H.H. Chan and F.D. Rossini, J. Chem. Thermodyn., 9, 915 (1977); doi:10.1016/0021-9614(77)90214-2.