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Vol. 26 No. 7 (2014): Vol 26 Issue 7

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Swelling Kinetics and Rheological Characterization of Methyl Acrylate-Vinyl Acetate-Acrylic Acid Hydrogels

https://doi.org/10.14233/ajchem.2014.15556
Muhammad Aslam Malana
Institute of Chemical Sciences, Bahauddin Zakariya University, Multan-60800, Pakistan
Gulistan Firdous
Institute of Chemical Sciences, Bahauddin Zakariya University, Multan-60800, Pakistan
Abeera Javed
Institute of Chemical Sciences, Bahauddin Zakariya University, Multan-60800, Pakistan
Zafar Iqbal Zafar
Institute of Chemical Sciences, Bahauddin Zakariya University, Multan-60800, Pakistan
Muhammad Saleem Khan
Centre of Excellence in Physical Chemistry, University of Peshawar, Peshawar, Pakistan

Corresponding Author(s) : Muhammad Aslam Malana

draslammalana@gmail.com

Asian Journal of Chemistry, Vol. 26 No. 7 (2014): Vol 26 Issue 7

Abstract

In the present studies, swelling kinetics of crosslinked methyl acrylate-vinyl acetate-acrylic acid (MA-VA-AA) hydrogels and rheological studies of uncrosslinked MA-VA-AA hydrogels have been undertaken. The swelling response of hydrogels to pH, temperature and concentration of methyl acrylate has been investigated. It was observed that equilibrium swelling (we) increased with pH and temperature whereas, it decreased with methyl acrylate contents. The value of 0.5 < n < 1 obtained in the present studies at all the temperatures, pH and methyl acrylate concentrations indicated non-fickian mechanism of the diffusion process. In order to evaluate kinetic order of swelling, Fick's model and Schott's model were applied to the experimental data. Better value of correlation coefficient (R2 > 0.96) obtained in case of Fick’s model showed that swelling behavior of the hydrogels followed first order kinetics. The values of fluidity index (n) obtained from the flow curves at all the temperatures were less than 1.0 indicating non-newtonian behavior of all the hydrogels. The magnitude of Bingham yield stress increased with methyl acrylate concentration and decreased with temperature. Consistency coefficient (K), however, increased with methyl acrylate concentration. This could be interpreted in terms of higher degree of entanglement in the gel containing greater contents of methyl acrylate. Maximum swelling of MA-VA-AA hydrogel at pH 8 suggests that it may be used as drug delivery device for delivering drug at colonic part of intestine (pH 7-8).

Keywords

Rheology Shear thinning Swelling Methyl acrylate-vinyl acetate-acrylic acid hydrogel
Aslam Malana, M., Firdous, G., Javed, A., Iqbal Zafar, Z., & Saleem Khan, M. (2014). Swelling Kinetics and Rheological Characterization of Methyl Acrylate-Vinyl Acetate-Acrylic Acid Hydrogels. Asian Journal of Chemistry, 26(7), 1898–1904. https://doi.org/10.14233/ajchem.2014.15556
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References
  1. A. Thakur, R.K. Wanchoo and P. Singh, Chem. Biochem. Eng., 25, 181 (2011).
  2. J. Guzmán, M.T. Iglesias, E. Riande, V. Compañ and A. Andrio, Polymer, 38, 5227 (1997); doi:10.1016/S0032-3861(97)00039-6.
  3. M. Sen and O. Güven, Polymer, 39, 1165 (1998); doi:10.1016/S0032-3861(97)00391-1.
  4. H.V. Chavda and C.N. Patel, Trends Biomater. Artif. Organs, 24, 83 (2010).
  5. J.I. Ngadaonye, M.O. Cloonan, L.M. Geever and C.L. Higginbotham, J. Polym. Res., 18, 2307 (2011); doi:10.1007/s10965-011-9644-0.
  6. B.D. Johnson, D.J. Beebe and W. Crone, Mater. Sci. Eng. C, 24, 575 (2004); doi:10.1016/j.msec.2003.11.002.
  7. E. Ruel-Gariepy and J.C. Leroux, Eur. J. Pharm. Biopharm., 58, 409 (2004); doi:10.1016/j.ejpb.2004.03.019.
  8. Y. Huang, H. Yu and C. Xiao, Carbohydr. Polym., 69, 774 (2007); doi:10.1016/j.carbpol.2007.02.016.
  9. P. Gupta, K. Vermani and S. Gary, J. Res. Focus., 7, 569 (2002).
  10. S. Jin, M. Liu, F. Zhang, S. Chen and A. Niu, Polymer, 47, 1526 (2006); doi:10.1016/j.polymer.2006.01.009.
  11. J.M. Rosiak and F. Yoshii, Nucl. Instrum. Methods Phys. Res., 151, 56 (1999); doi:10.1016/S0168-583X(99)00118-4.
  12. S.L. Jahren, M.F. Butler, S. Adams and R.E. Cameron, Macromol. Chem. Phys., 211, 644 (2010); doi:10.1002/macp.200900560.
  13. X.H. Xia, J. Yih, N.A. D’Souza and Z.B. Hu, Polymer, 44, 3389 (2003); doi:10.1016/S0032-3861(03)00228-3.
  14. N.A. Peppas, P. Buresa and W. Leobandung, Eur. J. Pharm. Biopharm., 50, 27 (2000); doi:10.1016/S0939-6411(00)00090-4.
  15. B. Stubbe, B. Maris, G. Van den Mooter, S.C. De Smedt and J. Demeester, J. Control. Rel., 75, 103 (2001); doi:10.1016/S0168-3659(01)00367-4.
  16. S.K. Bajpai and S. Dubey, Iran. Polym. J., 13, 189 (2004).
  17. Z.I. Zafar, M.A. Malana and K. Momina, Polymer (Korea), 32, 219 (2008).
  18. A.P. Javadi and G.R. Mahdavinia, Turk. J. Chem., 30, 595 (2006).
  19. F. Jabbari and S. Nozari, Eur. Polym. J., 36, 2685 (2000); doi:10.1016/S0014-3057(00)00044-6.
  20. O. Zamoume, S. Thibault, G. Regnié, M.O. Mecherri, M. Fiallo and P. Sharrock, Mater. Sci. Eng. C, 31, 1352 (2011); doi:10.1016/j.msec.2011.04.020.
  21. M.K. Krusic and J. Filipovic, Polymer, 47, 148 (2006); doi:10.1016/j.polymer.2005.11.002.
  22. P.L. Ritger and N.A. Peppas, J. Control. Rel., 5, 23 (1987); doi:10.1016/0168-3659(87)90034-4.
  23. J.Z. Yi and L.M. Zhang, Eur. Polym. J., 43, 3215 (2007); doi:10.1016/j.eurpolymj.2007.05.023.
  24. I.W. Velthoen, J. van Beek, P.J. Dijkstra and J. Feijen, React. Funct. Polym., 71, 245 (2011); doi:10.1016/j.reactfunctpolym.2010.08.007.
  25. E.S. Gil and S.A. Hudson, Prog. Polym. Sci., 29, 1173 (2004); doi:10.1016/j.progpolymsci.2004.08.003.
  26. D.D. Atapattu, R.P. Chhabra and P.H.T. Uhlherr, J. Non-Newtonian Fluid Mech., 38, 31, (1990); doi:10.1016/0377-0257(90)85031-S.
  27. D. Feys, R. Verhoeven and G. De Schutter, Appl. Rheol., 17, 56244 (2007); doi:10.3933/ApplRheol-17-56244.
  28. A. Yahia and K.H. Khayat, Cement Concret Res, 31, 731 (2001); doi:10.1016/S0008-8846(01)00476-8.
  29. R.A.F. Cabral, J.A.W. Gut, V.R.N. Telis and J. Telis-Romero, Braz. J. Chem. Eng., 27, 563 (2010); doi:10.1590/S0104-66322010000400008.
  30. S. Delgado, R. Villarroel and E. Gonzalez, J. Membr. Sci., 311, 173 (2008); doi:10.1016/j.memsci.2007.12.019.
  31. M.T. Islam, N. Rodríguez-Hornedo, S. Ciotti and C. Ackermann, J. Pharm. Res., 21, 1192 (2004); doi:10.1023/B:PHAM.0000033006.11619.07.
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