A New Xanthone from Garcinia oligantha and Its Cytotoxicity

Yan-Qing Ye; Cong-Fang Xia; Xiang-Li Li; Yun-Hua Qin; Gang Du; Qiu-Fen Hu; Xue-Mei Gao

doi:10.14233/ajchem.2014.15583A

Issue

Vol. 26 No. 7 (2014): Vol 26 Issue 7

Issue Published : March 22, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

A New Xanthone from Garcinia oligantha and Its Cytotoxicity

https://doi.org/10.14233/ajchem.2014.15583A

Yan-Qing Ye

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Cong-Fang Xia

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Xiang-Li Li

Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R China

Yun-Hua Qin

Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R China

Gang Du

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Qiu-Fen Hu

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Xue-Mei Gao

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Corresponding Author(s) : Xue-Mei Gao

gao_xuemei@hotmail.com

Asian Journal of Chemistry, Vol. 26 No. 7 (2014): Vol 26 Issue 7
Article Published : March 31, 2014

Abstract

A new xanthone, methyl 6-(2-acetoxyethyl)-4,8-dihydroxy-9-oxo-9H-xanthene-1-carboxylate (1), was isolated from the stems of Garcinia oligantha. Its structure was elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound 1 was tested for their cytotoxicities against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) and it exhibited moderate cytotoxicity against NB4, PC3 and MCF7 cell with IC₅₀ values of 6.2, 3.8 and 5.4 μM, respectively.

Keywords

Xanthone Garcinia oligantha Cytotoxicities

Ye, Y.-Q., Xia, C.-F., Li, X.-L., Qin, Y.-H., Du, G., Hu, Q.-F., & Gao, X.-M. (2014). A New Xanthone from Garcinia oligantha and Its Cytotoxicity. Asian Journal of Chemistry, 26(7), 1957–1959. https://doi.org/10.14233/ajchem.2014.15583A

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References

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References

X.W. Li, J. Li and P.F. Stevens, Flora of China, Chinese Science Press: Beijing, Vol. 13, p. 1267 (2007).

Y.J. Xu, Y.H. Lai, Z. Imiyabir and S.H. Goh, J. Nat. Prod., 64, 1191 (2001); doi:10.1021/np0101393.

X.M. Gao, T. Yu, M.Z. Cui, J.X. Pu, X. Du, Q.B. Han, Q.F. Hu, T.C. Liu, K.Q. Luo and H.X. Xu, Bioorg. Med. Chem. Lett., 22, 2350 (2012); doi:10.1016/j.bmcl.2012.01.068.

J.H. Wu, Y.T. Tung, C.F. Chyu, S.C. Chien, S.Y. Wang, S.T. Chang and Y.H. Kuo, J. Wood Sci., 54, 383 (2008); doi:10.1007/s10086-008-0961-9.

Z.H. Mbwambo, M.C. Kapingu, M.J. Moshi, F. Machumi, S. Apers, P. Cos, D. Ferreira, J.P.J. Marais, D. Vanden Berghe, L. Maes, A. Vlietinck and L. Pieters, J. Nat. Prod., 69, 369 (2006); doi:10.1021/np050406v.

X.-M. Gao, T. Yu, F.S.F. Lai, J.-X. Pu, C.-F. Qiao, Y. Zhou, X. Liu, J.-Z. Song, K.Q. Luo and H.-X. Xu, Tetrahedron Lett., 51, 2442 (2010); doi:10.1016/j.tetlet.2010.02.147.

L.-J. Zhang, C.-T. Chiou, J.-J. Cheng, H.-C. Huang, L.-M.Y. Kuo, C.-C. Liao, K.F. Bastow, K.-H. Lee and Y.-H. Kuo, J. Nat. Prod., 73, 557 (2010); doi:10.1021/np900620y.

X.M. Gao, T. Yu, F.S.F. Lai, Y. Zhou, X. Liu, C.F. Qiao, J.Z. Song, S.L. Chen, K.Q. Luo and H.X. Xu, Bioorg. Med. Chem., 18, 4957 (2010); doi:10.1016/j.bmc.2010.06.014.

C. Ito, M. Itoigawa, Y. Mishina, H. Tomiyasu, M. Litaudon, J.P. Cosson, T. Mukainaka, H. Tokuda, H. Nishino and H. Furukawa, J. Nat. Prod., 64, 147 (2001); doi:10.1021/np000333+.

V. Rukachaisirikul, W. Naklue, S. Phongpaichit, N.H. Towatana and K. Maneenoon, Tetrahedron, 62, 8578 (2006); doi:10.1016/j.tet.2006.06.059.

S. Deachathai, W. Mahabusarakam, S. Phongpaichit and W.C. Taylor, Phytochemistry, 66, 2368 (2005); doi:10.1016/j.phytochem.2005.06.025.

M. Ilyas, M. Kamil, M. Parveen and M.S. Khan, Phytochemistry, 36, 807 (1994); doi:10.1016/S0031-9422(00)89823-4.

Q.B. Han, S.F. Lee, C.F. Qiao, Z.D. He, J.Z. Song, H.D. Sun and H.X. Xu, Chem. Pharm. Bull. (Tokyo), 53, 1034 (2005); doi:10.1248/cpb.53.1034.

V. Rukachaisirikul, S. Saelim, P. Karnsomchoke and S. Phongpaichit, J. Nat. Prod., 68, 1222 (2005); doi:10.1021/np050131j.

X.M. Gao, T. Yu, M.Z. Cui, J.X. Pu, X. Du, Q.B. Han, Q.F. Hu, T.C. Liu, K.Q. Luo and H.X. Xu, Bioorg. Med. Chem., 22, 2350 (2012); doi:10.1016/j.bmcl.2012.01.068.

T. Mosmann, J. Immunol. Methods, 65, 55 (1983); doi:10.1016/0022-1759(83)90303-4.

Issue

Vol. 26 No. 7 (2014): Vol 26 Issue 7

A New Xanthone from Garcinia oligantha and Its Cytotoxicity

Corresponding Author(s) : Xue-Mei Gao

Abstract

Keywords

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