A New Dibenzocyclooctadiene Lignan from the Stems of Schisandra neglecta and It Cytotoxicities

Yan-Qing Ye; Cong-Fang Xia; Yin-Ke Li; Xian-Xue Wu; Gang Du; Qiu-Fen Hu; Xue-Mei Gao

doi:10.14233/ajchem.2014.15583

Issue

Vol. 26 No. 7 (2014): Vol 26 Issue 7

Issue Published : March 22, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

A New Dibenzocyclooctadiene Lignan from the Stems of Schisandra neglecta and It Cytotoxicities

https://doi.org/10.14233/ajchem.2014.15583

Yan-Qing Ye

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunmig 650031, P.R. China

Cong-Fang Xia

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunmig 650031, P.R. China

Yin-Ke Li

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunmig 650031, P.R. China ;Collge of Resource and Environment, Yuxi Normal University, Yuxi 653100, P.R. China

Xian-Xue Wu

Collge of Resource and Environment, Yuxi Normal University, Yuxi 653100, P.R. China

Gang Du

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunmig 650031, P.R. China

Qiu-Fen Hu

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunmig 650031, P.R. China

Xue-Mei Gao

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunmig 650031, P.R. China

Corresponding Author(s) : Xue-Mei Gao

gao_xuemei@hotmail.com

Asian Journal of Chemistry, Vol. 26 No. 7 (2014): Vol 26 Issue 7
Article Published : March 31, 2014

Abstract

A new dibenzocyclooctadiene lignan, neglignan H (1) was isolated from the stems of Schisandra neglecta. The structures of (1) was elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound 1 was tested for its cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) and compound 1 exhibited modest cytotoxicity against NB4, A549 and MCF7 cell with IC₅₀ values of 8.1, 7.4 and 6.7 μM, respectively.

Keywords

Schisandra neglecta Lignan Cytotoxicities

Ye, Y.-Q., Xia, C.-F., Li, Y.-K., Wu, X.-X., Du, G., Hu, Q.-F., & Gao, X.-M. (2014). A New Dibenzocyclooctadiene Lignan from the Stems of Schisandra neglecta and It Cytotoxicities. Asian Journal of Chemistry, 26(7), 1948–1950. https://doi.org/10.14233/ajchem.2014.15583

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References

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References

Committee of Pharmacopoeia of China, Pharmacopoeia of the People's Republic of China (Part 1), Pharmacopoeia Commission of the Ministry of Public Health of PRC, Beijing, China, pp. 454-455 (1990).

L.J. Xu, H.T. Liu, Y. Peng and P.G. Xiao, J. System. Evol., 46, 692 (2008).

J.B. Chang, J. Reiner and J.X. Xie, Chem. Rev., 105, 4581 (2005); doi:10.1021/cr050531b.

W.L. Xiao, R.T. Li, S.X. Huang, J.X. Pu and H.D. Sun, Nat. Prod. Rep., 25, 871 (2008); doi:10.1039/b719905h.

X.G. Li, Q. Gao, W. Wen, P.F. Zhang, F. Xiao and H.M. Luo, J. Chin. Med. Mat., 28, 156 (2005).

Y.X. Duan, J.L. Cao, R.R. Wen, G.Y. Yang, J.X. Pu, H.D. Sun, W.L. Xiao and G.P. Li, J. Asian Nat. Prod. Res., 13, 592 (2011); doi:10.1080/10286020.2011.576843.

M. Chen, X.M. Xu, Z.H. Liao, L. Dong, L. Li and C.Z. Huang, Molecules, 13, 548 (2008); doi:10.3390/molecules13030548.

M. Chen, Z.Z. Liao, X.M. Xu, Y. Wen, M. Sun, H.X. Zhang and W.X. Ma, Molecules, 13, 1148 (2008); doi:10.3390/molecules13051148.

G.-Y. Yang, Y.-K. Li, R.-R. Wang, X.-N. Li, W.-L. Xiao, L.-M. Yang, J.-X. Pu, Y.-T. Zheng and H.-D. Sun, J. Nat. Prod., 73, 915 (2010); doi:10.1021/np100067w.

G.-Y. Yang, R.-R. Wang, H.-X. Mu, Y.-K. Li, X.-N. Li, L.-M. Yang, Y.-T. Zheng, W.-L. Xiao and H.-D. Sun, J. Nat. Prod., 76, 250 (2013); doi:10.1021/np300745q.

Y. Ikeya, H. Taguchi, I. Yosioka, Y. Iitaka and H. Kobayashi, Chem. Pharm. Bull. (Tokyo), 27, 1395 (1979); doi:10.1248/cpb.27.1395.

Y. Ikeya, H. Taguchi, I. Yosioka and H. Kobayashi, Chem. Pharm. Bull. (Tokyo), 27, 1383 (1979); doi:10.1248/cpb.27.1383.

T. Mosmann, J. Immunol. Methods, 65, 55 (1983); doi:10.1016/0022-1759(83)90303-4.

Issue

Vol. 26 No. 7 (2014): Vol 26 Issue 7

A New Dibenzocyclooctadiene Lignan from the Stems of Schisandra neglecta and It Cytotoxicities

Corresponding Author(s) : Xue-Mei Gao

Abstract

Keywords

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