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Vol. 26 No. 7 (2014): Vol 26 Issue 7

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One-Pot Synthesis of Novel 3,5-Disubstituted-1,2,4-oxadiazoles from Indazole Carboxylic Acid Esters and Amidoximes

https://doi.org/10.14233/ajchem.2014.15564
Udutha Kumara Swamy
Laurus Labs Private Limited, IKP Knowledge Park, Turkapally, Shameerpet, Hyderabad-500 078, India
H. Rama Mohan
Laurus Labs Private Limited, IKP Knowledge Park, Turkapally, Shameerpet, Hyderabad-500 078, India
U. Viplava Prasad
Department of Organic Chemistry, Foods, Drugs and Water, Andhra University, Visakhapatnam-530 003, India
T. Suresh
Laurus Labs Private Limited, IKP Knowledge Park, Turkapally, Shameerpet, Hyderabad-500 078, India
T. Laxmi Kumar
Laurus Labs Private Limited, IKP Knowledge Park, Turkapally, Shameerpet, Hyderabad-500 078, India

Corresponding Author(s) : Udutha Kumara Swamy

kumarudutha@gmail.com

Asian Journal of Chemistry, Vol. 26 No. 7 (2014): Vol 26 Issue 7

Abstract

An efficient and high-yielding one-pot synthesis of 3,5-disubstituted-1,2,4-oxadiazoles from indazole carboxylic acid methyl esters and amidoximes is described. In this study a series of novel 3,5-disubstituted-1,2,4-oxadiazoles (3a-d), (4a-d), (5a-d), (6a-d), (7a-d) were synthesized using amidoximes 2a-d and indazole carboxylic acid esters (3-6).

Keywords

Amidoximes Indazole carboxylic acid esters 1,2,4-Oxadiazoles
Kumara Swamy, U., Rama Mohan, H., Viplava Prasad, U., Suresh, T., & Laxmi Kumar, T. (2014). One-Pot Synthesis of Novel 3,5-Disubstituted-1,2,4-oxadiazoles from Indazole Carboxylic Acid Esters and Amidoximes. Asian Journal of Chemistry, 26(7), 1921–1930. https://doi.org/10.14233/ajchem.2014.15564
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