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Vol. 31 No. 11 (2019): Vol 31 Issue 11

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Variability of Curcumin, Demethoxycurcumin and Bisdemethoxycurcumin Contents in Ethanolic Extract from Ten Curcuma aeruginosa Roxb. Cultivated in West Java, Indonesia

https://doi.org/10.14233/ajchem.2019.22128
Waras Nurcholis
Department of Biochemistry, Bogor Agricultural University (IPB), Jl. Agatis, Kampus IPB Dramaga, Bogor 16680, West Java, Indonesia & Tropical Biopharmaca Research Center (Trop-BRC), Bogor Agricultural University (IPB), Jl. Taman Kencana, Kampus IPB Taman Kencana, Bogor 16128, West Java, Indonesia
https://orcid.org/0000-0001-7047-5093
Nurul Khumaida
Department of Agronomy and Horticulture, Bogor Agricultural University (IPB), Jl. Meranti, Kampus IPB Dramaga, Bogor 16680, West Java, Indonesia
Muhamad Syukur
Department of Agronomy and Horticulture, Bogor Agricultural University (IPB), Jl. Meranti, Kampus IPB Dramaga, Bogor 16680, West Java, Indonesia
https://orcid.org/0000-0003-0442-7688
Maria Bintang
Department of Biochemistry, Bogor Agricultural University (IPB), Jl. Agatis, Kampus IPB Dramaga, Bogor 16680, West Java, Indonesia

Corresponding Author(s) : Waras Nurcholis

wnurcholis@apps.ipb.ac.id

Asian Journal of Chemistry, Vol. 31 No. 11 (2019): Vol 31 Issue 11

Abstract

Ten accessions of Curcuma aeruginosa Roxb. were grown under the same environment in Bogor, West Java, Indonesia was investigated for curcumin, demethoxycurcumin and bisdemethoxycurcumin contents using HPLC. No significant variations were observed among C. aeruginosa accessions for all the studied compounds. According to the results, curcumin content (mg/100 g extract) varied between 1.08 in accession Kulonprogo to 3.19 in accession Gunung Kidul. The accessions Muara Bungo and Kulonprogo had the highest (1.66) and lowest (0.51) levels of demethoxycurcumin (mg/100 g extract). Also, bisdemethoxycurcumin content varied from 0.05 to 0.49 mg/100 g extract in accessions Ciampea Bogor and Purworejo, respectively. Finally, curcuminoid contents (mg/100 g extract), accumulation of curcumin, demethoxycurcumin and bisdemethoxycurcumin contents, ranged from 1.64 to 5.05 in accessions Kulonprogo and Gunung Kidul, respectively. Hierarchical cluster analysis showed that 10 accessions could be divided into three groups. Group 1 composed of Gunung Kidul, Muara Bungo, Pakem and Beringharjo accessions. These accessions characterized by high of curcumin, demethoxycurcumin, and bisdemethoxycurcumin contents. Group 2 formed two accessions (Klewer and Purworejo) that showed the high only bisdemethoxycurcumin content. Accessions of Kulonprogo, Losari Cirebon, Madura and Ciampea Bogor, in group 3, characterized by low curcumin, demethoxycurcumin and bisdemethoxycurcumin contents. In this study, Gunung Kidul, Muara Bungo, Pakem and Beringharjo accessions have a high in curcuminoid content that showed a high potential for use in future plant breeding programs.

Keywords

Bisdemethoxycurcumin Curcuma aeruginosa Roxb Curcumin Curcuminoid Demethoxycurcumin
Nurcholis, W., Khumaida, N., Syukur, M., & Bintang, M. (2019). Variability of Curcumin, Demethoxycurcumin and Bisdemethoxycurcumin Contents in Ethanolic Extract from Ten Curcuma aeruginosa Roxb. Cultivated in West Java, Indonesia. Asian Journal of Chemistry, 31(11), 2461–2465. https://doi.org/10.14233/ajchem.2019.22128
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References
  1. N.S. Dosoky and W.N. Setzer, Nutrients, 10, 1196 (2018); https://doi.org/10.3390/nu10091196.
  2. N. Akarchariya, S. Sirilun, J. Julsrigival and S. Chansakaowa, Asian Pac. J. Trop. Biomed., 7, 881 (2017); https://doi.org/10.1016/j.apjtb.2017.09.009.
  3. S. Andrina, N. Churiyah and N. Nuralih, Indo. J. Cancer Chemopreven., 6, 84 (2017); https://doi.org/10.14499/indonesianjcanchemoprev6iss3pp84-88.
  4. T.S.A.T. Kamazeri, O.A. Samah, M. Taher, D. Susanti and H. Qaralleh, Asian Pac. J. Trop. Med., 5, 202 (2012); https://doi.org/10.1016/S1995-7645(12)60025-X.
  5. P. Thaina, P. Tungcharoen, M. Wongnawa, W. Reanmongkol and S. Subhadhirasakul, J. Ethnopharmacol., 121, 433 (2009); https://doi.org/10.1016/j.jep.2008.10.022.
  6. N. Suphrom, G. Pumthong, N. Khorana, N. Waranuch, N. Limpeanchob and K. Ingkaninan, Fitoterapia, 83, 864 (2012); https://doi.org/10.1016/j.fitote.2012.03.017.
  7. W. Moelyono Moektiwardoyo, A. Tjitraresmi, Y. Susilawati, Y. Iskandar, E. Halimah and D. Zahryanti, Procedia Chem., 13, 134 (2014); https://doi.org/10.1016/j.proche.2014.12.017.
  8. E.N. Qomaliyah, I.M. Artika and W. Nurcholis, Int. J. Res. Pharm. Sci., 10,1650 (2019); https://doi.org/10.26452/ijrps.v10i3.1331.
  9. W. Nurcholis, L. Ambarsari and E.D. Purwakusumah, Int. J. Pharm. Tech. Res., 9, 175 (2016).
  10. W. Nurcholis, N. Khumaida, M. Syukur and M. Bintang, Asian J. Biochem., 11, 142 (2016); https://doi.org/10.3923/ajb.2016.142.148.
  11. A. Amalraj, A. Pius, S. Gopi and S. Gopi, J. Tradit. Complement. Med., 7, 205 (2017); https://doi.org/10.1016/j.jtcme.2016.05.005.
  12. L. Yang, Z. Zheng, C. Qian, J. Wu, Y. Liu, S. Guo, G. Li, M. Liu, X. Wang and D.L. Kaplan, J. Colloid Interface Sci., 496, 66 (2017); https://doi.org/10.1016/j.jcis.2017.01.115.
  13. Z. Hussain, H.E. Thu, M.W. Amjad, F. Hussain, T.A. Ahmed and S. Khan, Mater. Sci. Eng. C, 77, 1316 (2017); https://doi.org/10.1016/j.msec.2017.03.226.
  14. C. Changtam, H.P. de Koning, H. Ibrahim, M.S. Sajid, M.K. Gould and A. Suksamrarn, Eur. J. Med. Chem., 45, 941 (2010); https://doi.org/10.1016/j.ejmech.2009.11.035.
  15. H.S. Lim, S.H. Park, K. Ghafoor, S.Y. Hwang and J. Park, Food Chem., 124, 1577 (2011); https://doi.org/10.1016/j.foodchem.2010.08.016.
  16. N.P. Aditya, G. Chimote, K. Gunalan, R. Banerjee, S. Patankar and B. Madhusudhan, Exp. Parasitol., 131, 292 (2012); https://doi.org/10.1016/j.exppara.2012.04.010.
  17. Y. Panahi, A. Saadat, F. Beiraghdar, S.M. Hosseini Nouzari, H.R. Jalalian and A. Sahebkar, J. Funct. Foods, 6, 615 (2014); https://doi.org/10.1016/j.jff.2013.12.008.
  18. A. Tapal and P.K. Tiku, Food Chem., 130, 960 (2012); https://doi.org/10.1016/j.foodchem.2011.08.025.
  19. S. Rubagotti, S. Croci, E. Ferrari, G. Orteca, M. Iori, P.C. Capponi, A. Versari and M. Asti, J. Inorg. Biochem., 173, 113 (2017); https://doi.org/10.1016/j.jinorgbio.2017.05.002.
  20. N. Verma and S. Shukla, J. Appl. Res. Med. Aromat. Plants, 2, 105 (2015); https://doi.org/10.1016/j.jarmap.2015.09.002.
  21. W. Nurcholis, N. Khumaida, M. Syukur and M. Bintang, Molekul (Indonesia), 12, 133 (2017); https://doi.org/10.20884/1.jm.2017.12.2.350.
  22. W. Nurcholis, N. Khumaida, M. Syukur and M. Bintang, Asian Pac. J. Trop. Dis., 6, 887 (2016); https://doi.org/10.1016/S2222-1808(16)61152-0.
  23. W. Nurcholis, N. Khumaida, M. Syukur and D.M. Bintang, Indo. J. Agron., 44, 315 (2017); https://doi.org/10.24831/jai.v44i3.12762.
  24. G.K. Jayaprakasha, L. Jagan Mohan Rao and K.K. Sakariah, J. Agric. Food Chem., 50, 3668 (2002); https://doi.org/10.1021/jf025506a.
  25. J. Chong and J. Xia, Bioinformatics, 34, 4313 (2018); https://doi.org/10.1093/bioinformatics/bty528.
  26. M.J. Ratnambal, Plant Foods Hum. Nutr., 36, 243 (1986); https://doi.org/10.1007/BF01092043.
  27. R. Bos, T. Windono, H.J. Woerdenbag, Y.L. Boersma, A. Koulman and O. Kayser, Phytochem. Anal., 18, 118 (2007); https://doi.org/10.1002/pca.959.
  28. M. Lechtenberg, B. Quandt and A. Nahrstedt, Phytochem. Anal., 15, 152 (2004); https://doi.org/10.1002/pca.759.
  29. R. Li, F. Liu, X. Yang, L. Chen, F. Wang, G. Zhang, Q. Zhang, L. Zhang, Y. He, Y. Li, P. Lai, X. Chen, M. Ye, H. Xiao and H. Xiao, J. Funct. Foods, 52, 186 (2019); https://doi.org/10.1016/j.jff.2018.11.008.
  30. T. Awin, A. Mediani, Maulidiani, S.W. Leong, S.M. Muhd Faudzi, K. Shaari and F. Abas, J. Food Compos. Anal., 77, 66 (2019); https://doi.org/10.1016/j.jfca.2019.01.004.
  31. B. Sasikumar, Plant Genet. Resour., 3, 230 (2005); https://doi.org/10.1079/PGR200574.
  32. J. Lee, Y. Jung, J.-H. Shin, H. Kim, B. Moon, D. Ryu and G.-S. Hwang, Molecules, 19, 9535 (2014); https://doi.org/10.3390/molecules19079535.
  33. S.A. Gilani, A. Kikuchi, T. Shimazaki, N. Wicaksana, Wunna and K.N. Watanabe, Biochem. Syst. Ecol., 61, 186 (2015); https://doi.org/10.1016/j.bse.2015.06.020.
  34. N. Arya, O. Prakash, S. Kumar, Vivekanand and A.K. Pant, Asian Pac. J. Trop. Dis., 6, 70 (2016); https://doi.org/10.1016/S2222-1808(15)60987-2.
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