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Vol. 31 No. 11 (2019): Vol 31 Issue 11

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Synthesis, Molecular Docking and Radical Scavenging Activity of 1,2,4,5-Tetrasubstituted Imidazole Derivatives

https://doi.org/10.14233/ajchem.2019.22107
Somashekara Bhadrachar
Department of Chemistry, University College of Science, Tumkur University, Tumkur-572103, India & Department of Chemistry, Smt. Indira Gandhi Government First Grade Women′s College, Sagar-577401, India
Giriyapura R. Vijayakuma
Department of Chemistry, University College of Science, Tumkur University, Tumkur-572103, India
Kittappa M. Mahadevan
Department of Chemistry, Kuvempu University, P.G. Centre, Kadur-577548, India
Thippeswamy Basavaraja
Department of Chemistry, Government Science College, Chithradurga-577501, India

Corresponding Author(s) : Giriyapura R. Vijayakuma

vijaykumargr18@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 11 (2019): Vol 31 Issue 11

Abstract

A series of 1,2,4,5-tetrasubstituted imidazoles (2a-g) were synthesized using 1,2-diketone, 1-naphthaldehyde, substituted aromatic amine and ammonium acetate in the presence of ceric ammonium nitrate as a catalyst. The synthesized compounds were characterized by FT-IR, 1H NMR, Mass spectra and explored for their antioxidant activity by DPPH free radical scavenging assay method. Among the synthesized compounds 2a, 2e and 2f exhibit good antioxidant activities. Molecular docking study was also been performed to know the possible interactions between the synthesized compound and antioxidant receptor 3MNG.

Keywords

1,2,4,5-Tetrasubstituted imidazoles Ceric ammonium nitrate Antioxidant activity Molecular docking
Bhadrachar, S., Vijayakuma, G. R., Mahadevan, K. M., & Basavaraja, T. (2019). Synthesis, Molecular Docking and Radical Scavenging Activity of 1,2,4,5-Tetrasubstituted Imidazole Derivatives. Asian Journal of Chemistry, 31(11), 2448–2452. https://doi.org/10.14233/ajchem.2019.22107
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