Copyright (c) 2014 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
Synthesis and Characterization of 4,4'-Di(p-aminophenylethynyl)-6,6'-bis(N,N-bis(t-butoxycarbonylmethyl)amino methyl)-2,2'-bipyridine
Corresponding Author(s) : Yun-Hui Li
Asian Journal of Chemistry,
Vol. 26 No. 8 (2014): Vol 26 Issue 8
Abstract
To obtain a new solid phase time-resolved fluorescence immunoassay bifunctional chelate, a new intermediate compound, 4'-di(p-aminophenylethynyl)-6,6'-bis[N,N-bis(t-butoxycarbonylmethyl) amino methyl]-2,2'-bipyridine was synthesized using 4,4'-dinitro-2,2'-bipyridine-6,6'-dimethyl bis(trifluoroacetate) as the initial material by four steps viz., hydrolyzation, bromination, esterification and substitution. The structure of the compound was charactered by IR, 1H NMR and HRMS.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
- X.P. Xie and L. Zhang, Food Drug, 14, 203 (2012).
- J. Shen, D.Q. Lin and J. Xu, Life Sciences, 16, 55 (2004).
- Y.Q. Di, J. Shangluo Univ., 25, 29 (2011).
- L.H. Pan, M. Gao, M. Lin, C.L. Ding, W.W. Sun and J. Zhao, Spectrosc. Spectr. Anal., 22, 573 (2002).
- C.N. Yu, H.T. Li, L.H. Pan and L. Wang, Labeled Immunoassays Clin. Med., 16, 105 (2009).
- A. Tanaka, Y. Arai, S.N. Kim, J. Ham and T. Usuki, Asian Nat. Prod. Res., 13, 290 (2011).
- X.J. Cao, W.B. Xie, L.H. Pan, Y. Chang, S.Z. Cui, H.J. Zhang and D.D. Dang, Chem. J. Chin. Univ., 33, 1462 (2012).
- S. Drouet, A. Merhi, G. Argouarch, F. Paul, O. Mongin, M. Blanchard-Desce and C.O. Paul-Rot-h, Tetrahedron, 68, 98 (2012); doi:10.1016/j.tet.2011.10.081.
- Q.Q. Niu, L.H. Pan, S.Y. Ma, Z. Li, W.B. Xie, M. Lin and Q. Fu, J. Mol. Sci., 22, 401 (2006).
- O. Prat, E. Lopez and G. Mathis, Anal. Biochem., 195, 283 (1991); doi:10.1016/0003-2697(91)90331-M.
- E. Brunet, O. Juanes, R. Sedano and J.C. Rodriguez-Ubis, Org. Lett., 4, 213 (2002); doi:10.1021/ol0169527.
- V.-M. Mukkala and J.J. Kankare, Helv. Chim. Acta, 75, 1578 (1992). doi:10.1002/hlca.19920750512.
References
X.P. Xie and L. Zhang, Food Drug, 14, 203 (2012).
J. Shen, D.Q. Lin and J. Xu, Life Sciences, 16, 55 (2004).
Y.Q. Di, J. Shangluo Univ., 25, 29 (2011).
L.H. Pan, M. Gao, M. Lin, C.L. Ding, W.W. Sun and J. Zhao, Spectrosc. Spectr. Anal., 22, 573 (2002).
C.N. Yu, H.T. Li, L.H. Pan and L. Wang, Labeled Immunoassays Clin. Med., 16, 105 (2009).
A. Tanaka, Y. Arai, S.N. Kim, J. Ham and T. Usuki, Asian Nat. Prod. Res., 13, 290 (2011).
X.J. Cao, W.B. Xie, L.H. Pan, Y. Chang, S.Z. Cui, H.J. Zhang and D.D. Dang, Chem. J. Chin. Univ., 33, 1462 (2012).
S. Drouet, A. Merhi, G. Argouarch, F. Paul, O. Mongin, M. Blanchard-Desce and C.O. Paul-Rot-h, Tetrahedron, 68, 98 (2012); doi:10.1016/j.tet.2011.10.081.
Q.Q. Niu, L.H. Pan, S.Y. Ma, Z. Li, W.B. Xie, M. Lin and Q. Fu, J. Mol. Sci., 22, 401 (2006).
O. Prat, E. Lopez and G. Mathis, Anal. Biochem., 195, 283 (1991); doi:10.1016/0003-2697(91)90331-M.
E. Brunet, O. Juanes, R. Sedano and J.C. Rodriguez-Ubis, Org. Lett., 4, 213 (2002); doi:10.1021/ol0169527.
V.-M. Mukkala and J.J. Kankare, Helv. Chim. Acta, 75, 1578 (1992). doi:10.1002/hlca.19920750512.