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Formulation and in vitro Evaluation of Gastro Retentive Oral Hydrogel Tablets Containing Cefditoren
Corresponding Author(s) : N.C. Sarada
Asian Journal of Chemistry,
Vol. 26 No. 9 (2014): Vol 26 Issue 9
Abstract
Cefditoren pivoxil gastro retentive tablets were prepared to achieve the gastro retentive effect in order to improve its absorption and bioavailability. Oral hydrogel tablets were prepared by varying concentrations (CHT1-CHT7) of carbopol and sodium alginate. The pre-compression parameters and post compression parameters were within acceptable pharmacopeial limits. The swelling index indicates that the formulations prepared with sodium carbonate have good porosity. The in vitro dissolution behaviour for the formulation of (CHT7) containing carbopol (100 mg) and sodium alginate (20 mg) were found to have good controlled release of 91.45 % in the 12 h.
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- E.A. Balbisi, Pharmacotherapy, 22, 1278 (2002); doi:10.1592/phco.22.15.1278.33481.
- Spectracef, Physicians' Desk Reference, Montvale (NJ), Thompson PDR, 7, 2824 (2005).
- K.C. Waterman, Pharm. Dev. Technol., 12, 1 (2007); doi:10.1080/10837450601168680.
- J. Chen, W.E. Blevins, H. Park and K. Park, J. Control. Rel., 64, 39 (2000); doi:10.1016/S0168-3659(99)00139-X.
- R. Bushra, M.H. Shoaib, N. Aslam, D. Hashmat and M.U. Rehman, Pak. J. Pharm. Sci., 21, 113 (2008).
- L.V. Allen, N.G. Popvich and H.C. Ansel, in eds.: Lippincott Williams and Wilkins, Pharmaceutical Dosage Forms and Drug Delivery System, Wolters Kluwer Company, Philadelphia, Baltimore, edn. 8, p. 227 (2005).
- The United State Pharmacopoeia, (USP 24 NF 19), Convention INC., 1462, 1913 (2000).
- G. DiColo, A. Baggiani, Y. Zambito, G. Mollica, M. Geppi and M.F. Serafini, Int. J. Pharm., 310, 154 (2006); doi:10.1016/j.ijpharm.2005.12.002.
References
E.A. Balbisi, Pharmacotherapy, 22, 1278 (2002); doi:10.1592/phco.22.15.1278.33481.
Spectracef, Physicians' Desk Reference, Montvale (NJ), Thompson PDR, 7, 2824 (2005).
K.C. Waterman, Pharm. Dev. Technol., 12, 1 (2007); doi:10.1080/10837450601168680.
J. Chen, W.E. Blevins, H. Park and K. Park, J. Control. Rel., 64, 39 (2000); doi:10.1016/S0168-3659(99)00139-X.
R. Bushra, M.H. Shoaib, N. Aslam, D. Hashmat and M.U. Rehman, Pak. J. Pharm. Sci., 21, 113 (2008).
L.V. Allen, N.G. Popvich and H.C. Ansel, in eds.: Lippincott Williams and Wilkins, Pharmaceutical Dosage Forms and Drug Delivery System, Wolters Kluwer Company, Philadelphia, Baltimore, edn. 8, p. 227 (2005).
The United State Pharmacopoeia, (USP 24 NF 19), Convention INC., 1462, 1913 (2000).
G. DiColo, A. Baggiani, Y. Zambito, G. Mollica, M. Geppi and M.F. Serafini, Int. J. Pharm., 310, 154 (2006); doi:10.1016/j.ijpharm.2005.12.002.