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Vol. 31 No. 11 (2019): Vol 31 Issue 11

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Viscometric and Conductometric Studies of Doxycycline Hyclate in Water, Aqueous Glycine and L-Alanine Solutions at Different Temperatures

https://doi.org/10.14233/ajchem.2019.22215
Shashi Kant Sharma
Department of Chemistry, Himachal Pradesh University, Summer Hill, Shimla-171005, India
Poonam
Department of Chemistry, Himachal Pradesh University, Summer Hill, Shimla-171005, India
Nisha Sharma
Department of Chemistry, Himachal Pradesh University, Summer Hill, Shimla-171005, India

Corresponding Author(s) : Shashi Kant Sharma

drsklomesh@rediffmail.com

Asian Journal of Chemistry, Vol. 31 No. 11 (2019): Vol 31 Issue 11

Abstract

To investigate the behaviour of doxycycline hyclate in water, aqueous glycine and aqueous L-alanine solutions, the viscometric and conductometric studies have been conducted at different temperatures. Viscosity data has been used to derive the Jones-Dole viscosity B-coefficient, temperature derivative of B-coefficient (dB/dT), viscosity B-coefficient of transfer (ΔtrB), free energy of activation of viscous flow per mole of solvent (Δμ1o*) and solute (Δμ2o*) respectively, activation entropy (ΔS2o*) and activation enthalpy (ΔH2o*). Conductance data has been used to compute Walden product (Λmoηo) and temperature coefficient of Walden product (dΛmoηo/dT) for doxycycline hyclate in water, and in aqueous glycine and aqueous L-alanine solution. The positive values of B-coefficient, ΔtrB indicate the prevailing of hydrophilic-ionic interactions in the systems under examination. The negative values of dB/dT and positive values of temperature coefficient of Walden product infer structure maker tendency of doxycycline hyclate in water, and in aqueous glycine and aqueous L-alanine solution. Transfer energy parameters indicate the breaking of intermolecular bonds in transition state which means that formation of activated complex is unfavourable.

Keywords

Jones-Dole viscosity Activation entropy Activation enthalpy Walden product
Sharma, S. K., Poonam, ., & Sharma, N. (2019). Viscometric and Conductometric Studies of Doxycycline Hyclate in Water, Aqueous Glycine and L-Alanine Solutions at Different Temperatures. Asian Journal of Chemistry, 31(11), 2557–2566. https://doi.org/10.14233/ajchem.2019.22215
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