Efficient Synthesis of 5(4H)-Imidazolones and in vitro Antifungal Activity Studies Against Selected Phytopathogens

Christopher Voosala; Lakshmi Narasimha Murthy Yellajyosula; Viplava Prasad Uppuleti; Padma Suhasini Kilaru

doi:10.14233/ajchem.2014.15893

Issue

Vol. 26 No. 10 (2014): Vol 26 Issue 10

Issue Published : May 10, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Efficient Synthesis of 5(4H)-Imidazolones and in vitro Antifungal Activity Studies Against Selected Phytopathogens

https://doi.org/10.14233/ajchem.2014.15893

Christopher Voosala

Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam-530 003, India

Lakshmi Narasimha Murthy Yellajyosula

Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam-530 003, India

Viplava Prasad Uppuleti

Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam-530 003, India

Padma Suhasini Kilaru

Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam-530 003, India

Corresponding Author(s) : Christopher Voosala

chrissvoosala@yahoo.co.in

Asian Journal of Chemistry, Vol. 26 No. 10 (2014): Vol 26 Issue 10
Article Published : May 10, 2014

Abstract

A series of five new 1-(substituted phenyl)-2-phenyl-4-(substituted benzylidine)imidazole-5-one derivatives (or) 5(4H)-imidazolones have been synthesized adopting SiO₂, Al₂O₃-90 and Y-faujasite (Y-H type) zeolite as catalysts. These compounds were assayed for their antifungal activity on three different selected phytopathogens which disparately affects the Jowar crop (Sorghum vulgare) of poaceae family. Among the screened target molecules, compound 18 exhibited potent inhibitory activity compared to the standard drug bavistine, which is worth for further investigation.

Keywords

Y-faujasite zeolite Imidazolone Phytopathogens Antifungal activity

Voosala, C., Narasimha Murthy Yellajyosula, L., Prasad Uppuleti, V., & Suhasini Kilaru, P. (2014). Efficient Synthesis of 5(4H)-Imidazolones and in vitro Antifungal Activity Studies Against Selected Phytopathogens. Asian Journal of Chemistry, 26(10), 2873–2876. https://doi.org/10.14233/ajchem.2014.15893

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References

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References

A.C. Cuckler, A.B. Kupferberg and N. Hillman, Antibiot. Chemother., 5, 540 (1955).

H.K. Urman, O. Bulay, D.B. Clayson and P. Shubik, Cancer Lett., 1, 69 (1975); doi:10.1016/S0304-3835(75)95362-8.

W.B. Wright Jr. and H.J. Brabander, J. Org. Chem., 26, 4051 (1961); doi:10.1021/jo01068a098.

V. Niedbalia and I. Buctteher, Chem. Abstr., 94, 15732 (1981).

K.J. Shaw, P.W. Erhardt, A.A. Hagedom, C.A. Pease, W.R. Ingebretsen and J.R. Wiggins, J. Med. Chem., 35, 1267 (1992); doi:10.1021/jm00085a014.

A. Nefzi, J.M. Ostresh and R.A. Houghten, Chem. Rev., 97, 449 (1997); doi:10.1021/cr960010b.

J.W. Cornforth and H.T. Huang, J. Chem. Soc., 731 (1948); doi:10.1039/jr9480000731.

H. Lehr, S. Karlan and M.W. Goldberg, J. Am. Chem. Soc., 75, 3640 (1953); doi:10.1021/ja01111a011.

L.D.S. Yadav and S. Singh, Synthesis, 63 (2003); doi:10.1055/s-2003-36257.

Z. Hell, A. Cwik, Z. Finta and Z. Horváth, J. Mol. Catal. A, 184, 191 (2002); doi:10.1016/S1381-1169(01)00518-0.

R. Roy, Science, 238, 1664 (1987); doi:10.1126/science.238.4834.1664.

A.L. McKenna in Kirk-othmer, Encyclopedia of Chemical Technology, Aluminium Carboxylates, Wiley, New York, vol. 2, p. 273 (1991).

Y.L.N. Murthy, V. Christopher, U.V. Prasad, P.B. Bisht, D.V. Ramanaih, B.S. Kalanoor and S.A. Ali, Synth. Met., 160, 535 (2010); doi:10.1016/j.synthmet.2009.11.029.

K. Smith, M. Butters and B. Nay, Synthesis, 1985, 1157 (1985); doi:10.1055/s-1985-31462.

P. Ratnasamy, A.P. Singh and S. Sharma, Appl. Catal. A, 135, 25 (1996); doi:10.1016/0926-860X(95)00210-3.

S.A. Siddiqui, S.R. Bhusare and D.V. Jarikote, Bull. Korean Chem. Soc., 22, 1033 (2001).

C.P. Pauli and P. Bazerque, Acta Biol. Med. Exper., 15, 113 (1990).]

P.R. Murray, E.J. Baron and M.A. Pfaller, Manual of clinical Microbiology, ASM Press, Washington D.C., edn 6 (1995).

Issue

Vol. 26 No. 10 (2014): Vol 26 Issue 10

Efficient Synthesis of 5(4H)-Imidazolones and in vitro Antifungal Activity Studies Against Selected Phytopathogens

Corresponding Author(s) : Christopher Voosala

Abstract

Keywords

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