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Vol. 31 No. 10 (2019): Vol 31 Issue 10

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Synthesis and Biological Evaluation of Furo[3,2-c]pyrazole-5-carbimidates

https://doi.org/10.14233/ajchem.2019.21971
Sravanthi Siliveri
Department of Pharmaceutical Chemistry, G. Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad-500028, India; Department of Pharmacy, Osmania University College of Technology (OUCT), Osmania University, Hyderabad-500007, India
https://orcid.org/0000-0002-3738-3004
Harinadha Babu Vamaraju
Department of Pharmaceutical Chemistry, G. Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad-500028, India
Shivaraj
Department of Chemistry, Osmania University, Hyderabad-500007, India

Corresponding Author(s) : Sravanthi Siliveri

sravanthisiliveri@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 10 (2019): Vol 31 Issue 10

Abstract

In the present work, novel pyrazole fused dihydrofurans synthesized via a chronological addition of N-chloro succinimide and base piperidine to pyrano[3,2-c]pyrazole carbonitrile derivatives in methanol medium. Oxidative difunctionalization was done with the reagent N-chloro succinimide by the addition of both chlorine and alkoxy groups crosswise the chromene double bond. The addition of base results in the construction of dihydrofuran derivatives by ring contraction. The structures of newly synthesized compounds were characterized on the basis of physical and spectral data. Synthesized compounds were evaluated for antibacterial and anti-inflammatory activities. All the compounds exhibited significant antibacterial activity against all the four strains of bacteria and their MICs ranged between 1.56 and 12.55 μg/mL. In anti-inflammatory screening, among all the tested compounds, compounds 7, 8, 9, 11, 12, 13, 14, 16, 17 and 18 exhibited significant protection against the edema formation at a concentration of 100 mg/kg.

Keywords

N-Chloro succinimide Piperidine Pyrano[3,2-c]pyrazole carbonitriles Antibacterial activity Anti-inflammatory activity
Siliveri, S., Vamaraju, H. B., & Shivaraj, . (2019). Synthesis and Biological Evaluation of Furo[3,2-c]pyrazole-5-carbimidates. Asian Journal of Chemistry, 31(10), 2389–2393. https://doi.org/10.14233/ajchem.2019.21971
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