Pharmacological Activities of Leaves Extract of Calotropis procera (Asclepiadaceae)

Santosh Dattatraya Ghule; Gali Vidyasagar; Anil Bhandari; Praveen Sharma; Sachin Jain; Abhay Jain

doi:10.14233/ajchem.2014.16365

Issue

Vol. 26 No. 10 (2014): Vol 26 Issue 10

Issue Published : May 10, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Pharmacological Activities of Leaves Extract of Calotropis procera (Asclepiadaceae)

https://doi.org/10.14233/ajchem.2014.16365

Santosh Dattatraya Ghule

Jodhpur National University, Jodhpur-342 006, India

Gali Vidyasagar

Veerayatan Institute of Pharmacy, Mandvi-370 460, India

Anil Bhandari

Jodhpur National University, Jodhpur-342 006, India

Praveen Sharma

College of Pharmacy, IPS Academy, Indore-452 012, India

Sachin Jain

College of Pharmacy, IPS Academy, Indore-452 012, India

Abhay Jain

Millenium College of Pharmacy, Bhopal-462 036, India

Corresponding Author(s) : Santosh Dattatraya Ghule

ghulesantosh1284@gmail.com

Asian Journal of Chemistry, Vol. 26 No. 10 (2014): Vol 26 Issue 10
Article Published : May 10, 2014

Abstract

Ethanolic extract of leaves of Calotropis procera (Asclepiadaceae) was tested for CNS activity like anticonvulsant, sedative and skeletal muscle relaxant activity. The extract of leaves of Calotropis procera orally in experimental animals at the dose level of 100, 200 and 500 mg/kg body weight. The anticonvulsant properties were studied on maximal electroshock test (MES) strychnine and PTZ-induced seizures model. Sedative property studied using actophotometer and skeletal muscle relaxant property studied using rotarod. C. procera ethanolic extract protected rats against maximal electroshock (MES) induced seizures. But had no or a moderate effect only against strychnine and PTZ-induced seizures. There was a decrease in the locomotor activity. The fall off time (motor coordination) was also decreased. No mortality was seen upto the dose of 2 g/kg. With these effects, the leaves of C. procera possess anticonvulsant, sedative and muscle relaxant effect that might explain its use as a traditional medicine.

Keywords

Calotropis procera Maximal electroshock Strychnine Pentylentetrazole Actophotometer Muscle relaxant

Dattatraya Ghule, S., Vidyasagar, G., Bhandari, A., Sharma, P., Jain, S., & Jain, A. (2014). Pharmacological Activities of Leaves Extract of Calotropis procera (Asclepiadaceae). Asian Journal of Chemistry, 26(10), 3006–3008. https://doi.org/10.14233/ajchem.2014.16365

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References

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References

K.R. Kirtikar and B.D. Basu, Indian Medicinal Plants, Lolit Mohan Basu, Allahabad, India (1999).

V.L. Kumar and S. Arya, Recent Progress in Medicinal Plants, 11, 373 (2006).

S. Samvatsar and V.B. Diwanji, J. Ethnopharmacol., 73, 313 (2000); doi:10.1016/S0378-8741(00)00274-9.

A. Basu, T. Sen, R.N. Ray and A.K. Nag Chaudhuri, Fitoterapia, 63, 507 (1992).

V.L. Kumar and N. Basu, J. Ethnopharmacol., 44, 123 (1994); doi:10.1016/0378-8741(94)90078-7.

S. Dewan, H. Sangraula and V.L. Kumar, J. Ethnopharmacol., 73, 307 (2000); doi:10.1016/S0378-8741(00)00272-5.

S. Dewan, S. Kumar and V.L. Kumar, Indian J. Pharmacol., 32, 252 (2000).

S. Arya and V.L. Kumar, Mediators Inflamm., 2005, 228 (2005); doi:10.1155/MI.2005.228.

S. Roy, R. Sehgal, B.M. Padhy and V.L. Kumar, J. Ethnopharmacol., 102, 470 (2005); doi:10.1016/j.jep.2005.06.026.

T. Choedon, G. Mathan, S. Arya, V.L. Kumar and V. Kumar, World J. Gastroenterol., 12, 2517 (2006).

J.S. Mossa, M. Tariq, A. Mohsin, A.M. Ageel, M.A. Al-Yahya, M.S. Al-Said and S. Rafatullah, Am. J. Chin. Med., 19, 223 (1991); doi:10.1142/S0192415X91000302.

S.K. Kulkarni, Handbook of Experimental Pharmacology, Vallabh Prakashan, pp. 131-133 (2010).

N. Choudhary, K.R.V. Bijjem and A.N. Kalia, J. Ethnopharmacol., 135, 238 (2011); doi:10.1016/j.jep.2011.02.019.

H.G. Vogel, Drug Discovery and Evaluation, Springer-Verlag, Berlin Heidelberg, pp. 422-23 (2002).

H.S. White, Epilepsia, 38(s1), S9 (1997); doi:10.1111/j.1528-1157.1997.tb04523.x.

W. Loscher, Epilepsy Res., 50, 105 (2002); doi:10.1016/S0920-1211(02)00073-6.

M.A. Rogawski and R.J. Porter, Pharmacol. Rev., 42, 223 (1990).

R.L. MacDonald and K.M. Kelly, Epilepsia, 36(s2), S2 (1995); doi:10.1111/j.1528-1157.1995.tb05996.x.

Issue

Vol. 26 No. 10 (2014): Vol 26 Issue 10

Pharmacological Activities of Leaves Extract of Calotropis procera (Asclepiadaceae)

Corresponding Author(s) : Santosh Dattatraya Ghule

Abstract

Keywords

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