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Vol. 26 No. 10 (2014): Vol 26 Issue 10

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New Validated Carbon Paste and Modified Carbon Nanotubes Sensors for Selective Determination of Pantoprazole Sodium

https://doi.org/10.14233/ajchem.2014.16611
Nawal Ahmad Alarfaj
Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia
Maha Farouq El-Tohamy
Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia ;Department of Chemistry, College of Science, Al Azhar University, Cairo, Egypt

Corresponding Author(s) : Nawal Ahmad Alarfaj

nalarfaj@hotmail.com

Asian Journal of Chemistry, Vol. 26 No. 10 (2014): Vol 26 Issue 10

Abstract

New validated carbon paste and chemically modified carbon nanotubes (MCNTs) sensors for determination of pantoprazole sodium (PA) were developed. The developed method was based on the fabrication of two types of sensors carbon paste (I), and modified carbon nanotubes (II). The employed sensors were fabricated using electroactive materials pantoprazole-phosphomolybdate (PA-PM). The performance characteristics of the proposed sensors were carefully studied. The sensors exhibited nearly Nernstain responses (55 ± 0.3 and 57.3 ± 0.8 mV decade-1) for pantoprazole-phosphomolybdate carbon paste and modified carbon nanotubes sensors at 25 °C over drug concentration ranges (1 × 10-6-1 × 10-3 and 1 × 10-7-1 × 10-2 mol L-1) with lower detection limits of (9.1 × 10-8 and 9.8 × 10-9 mol L-1) for the previously mentioned sensors, respectively. The fabricated sensors were safely used at pH 4-8 and displayed good isothermal coefficients 0.00105 and 0.00042 V °C-1 for pantoprazole-phosphomolybdate carbon paste and modified carbon nanotubes sensors, respectively. The influence of common and possible interfering species, pharmaceutical additives and some related pharmacological action drugs was investigated using both separate solution and mixed solution methods. No interference was found. The stability indicating using forced degradation of pantoprazole sodium was also studied. The results of the proposed method were validated and statistically analyzed by recoveries studies and compared with those obtained from previously reported methods. The proposed method was successfully applied for quantification of the investigated drug in pure form, its dosage forms and biological fluids.

Keywords

Pantoprazole sodium Carbon paste sensor Modified carbon nanotubes sensor Biological fluids Dosage forms
Ahmad Alarfaj, N., & Farouq El-Tohamy, M. (2014). New Validated Carbon Paste and Modified Carbon Nanotubes Sensors for Selective Determination of Pantoprazole Sodium. Asian Journal of Chemistry, 26(10), 3039–3046. https://doi.org/10.14233/ajchem.2014.16611
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