Determination of Promethazine in Pharmaceutical Samples by Using Graphene Modified Electrode

Le Chen; Fanghui Wu; Lichun Chen; Jie Mei; Xianwen Wei

doi:10.14233/ajchem.2014.15861

Issue

Vol. 26 No. 11 (2014): Vol 26 Issue 11

Issue Published : May 25, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Determination of Promethazine in Pharmaceutical Samples by Using Graphene Modified Electrode

https://doi.org/10.14233/ajchem.2014.15861

Le Chen

School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan 243002, Anhui Province, P.R. China

Fanghui Wu

School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan 243002, Anhui Province, P.R. China

Lichun Chen

School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan 243002, Anhui Province, P.R. China

Jie Mei

School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan 243002, Anhui Province, P.R. China

Xianwen Wei

School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan 243002, Anhui Province, P.R. China

Corresponding Author(s) : Fanghui Wu

ahutsjz@126.com

Asian Journal of Chemistry, Vol. 26 No. 11 (2014): Vol 26 Issue 11
Article Published : May 27, 2014

Abstract

A glass carbon electrode modified with functionalized graphene has been fabricated due to its elusive two-dimentional structure and unique electronic properties. Electrochemical experiments indicated the modified electrode showed a preferable electrocatalytic activity for the oxidation of promethazine. Under the optimum conditions, the increase of response current is proportional to the promethazine concentration in the range of 2.0 × 10^–6 and 1.0 × 10^–3 M, with the detection limit of 4.2 × 10^–7 M. In addition, the developed sensor shows acceptable stability and reproducibility. These results demonstrate the viability of the use of graphene modified electrode as a potential amperometric sensor for pharmaceutical and clinical measurements.

Keywords

Graphene Promethazine Modified electrode Measurement

Chen, L., Wu, F., Chen, L., Mei, J., & Wei, X. (2014). Determination of Promethazine in Pharmaceutical Samples by Using Graphene Modified Electrode. Asian Journal of Chemistry, 26(11), 3171–3174. https://doi.org/10.14233/ajchem.2014.15861

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G.W. Ponder and J.T. Stewart, J. Pharm. Biomed. Anal., 13, 1161 (1995); doi:10.1016/0731-7085(95)01527-R.

M.J. Ruedas Rama, A. Ruiz Medina and A. Molina Díaz, J. Pharm. Biomed. Anal., 35, 1027 (2004); doi:10.1016/j.jpba.2004.03.010.

M.J. Saif and J. Anwar, Talanta, 67, 869 (2005); doi:10.1016/j.talanta.2005.03.034.

Q. Zhang, X.C. Zhan, C.R. Li, T. Lin, L.L. Li, X.D. Yin, N. He and Y. Shi, Int. J. Pharm., 302, 10 (2005); doi:10.1016/j.ijpharm.2005.05.043.

S.M. Sultan, Y.A.M. Hassan and A.M. Abulkibash, Talanta, 59, 1073 (2003); doi:10.1016/S0039-9140(03)00016-X.

F.J. Lara, A.M. García-Campãna, F. Alés-Barrero and J.M. Bosque-Sendra, Anal. Chim. Acta, 535, 101 (2005); doi:10.1016/j.aca.2004.11.081.

M. Wójciak-Kosior, A. Skalska and A. Matysik, J. Pharm. Biomed. Anal., 41, 286 (2006); doi:10.1016/j.jpba.2005.10.035.

M.C. Quintana, M.H. Blanco, J. Lacal and L. Hermandez, Talanta, 59, 417 (2003); doi:10.1016/S0039-9140(02)00519-2.

R.I. Baxter, G. Svehla, B. Kerr and A.D. Woolfson, Anal. Chim. Acta, 164, 171 (1984); doi:10.1016/S0003-2670(00)85629-9.

Y.N. Ni, L. Wang and S. Kokot, Anal. Chim. Acta, 439, 159 (2001); doi:10.1016/S0003-2670(01)01038-8.

Z.S. Yang, J. Zhao, D.P. Zhang and Y.C. Liu, Anal. Sci., 23, 569 (2007); doi:10.2116/analsci.23.569.

T. Alizadeh and M. Akhoundian, Electrochim. Acta, 55, 5867 (2010); doi:10.1016/j.electacta.2010.05.037.

M.G. Li, S.D. Xu, M. Tang, L. Liu, F. Gao and Y.L. Wang, Electrochim. Acta, 56, 1144 (2011); doi:10.1016/j.electacta.2010.10.034.

F. Li, J.J. Li, Y. Feng, L.M. Yang and Z.F. Du, Sens. Actuators B, 157, 110 (2011); doi:10.1016/j.snb.2011.03.033.

M. Pumera, A. Ambrosi, A. Bonanni, E.L.K. Chng and H.L. Poh, TrAC Trends Analyt. Chem., 29, 954 (2010); doi:10.1016/j.trac.2010.05.011.

C.-L. Sun, H.-H. Lee, J.-M. Yang and C.-C. Wu, Biosens. Bioelectron., 26, 3450 (2011); doi:10.1016/j.bios.2011.01.023.

H.X. Luo, Z.J. Shi, N.Q. Li, Z.N. Gu and Q.K. Zhuang, Anal. Chem., 73, 915 (2001); doi:10.1021/ac000967l.

J.Y. Qu, Y. Shen, X.H. Qu and S.J. Dong, Chem. Commun., 34 (2004); doi:10.1039/b311038a.

P. Xiao, W. Wu, J. Yu and F. Zhao, Int. J. Electrochem. Sci., 2, 149 (2007).

D. Daniel and I.G.R. Gutz, Anal. Chim. Acta, 494, 215 (2003); doi:10.1016/S0003-2670(03)00903-6.

Q. Song and L. Putcha, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 763, 9 (2001); doi:10.1016/S0378-4347(01)00351-6.

Z.S. Yang, J. Zhao, D.P. Zhang and Y.C. Liu, Anal. Sci., 23, 569 (2007); doi:10.2116/analsci.23.569.

Issue

Vol. 26 No. 11 (2014): Vol 26 Issue 11

Determination of Promethazine in Pharmaceutical Samples by Using Graphene Modified Electrode

Corresponding Author(s) : Fanghui Wu

Abstract

Keywords

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