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Vol. 26 No. 11 (2014): Vol 26 Issue 11

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Synthesis, Crystal Structure and Antibacterial Activity of 2-(p-Tolyl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole

https://doi.org/10.14233/ajchem.2014.15892
Xianping Liu
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, P.R. China
Daohang He
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, P.R. China

Corresponding Author(s) : Daohang He

cehdh@scut.edu.cn

Asian Journal of Chemistry, Vol. 26 No. 11 (2014): Vol 26 Issue 11

Abstract

The compound 2-(p-tolyl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole (m.f. C18H18N2O4) was synthesized and characterized by 1H NMR, 13C NMR, MS and X-ray single crystal diffraction analysis. In the crystal structure, the two phenyl rings and the 1,3,4-oxadiazole ring are nearly coplanar with the dihedral angles 4.55, 1.13 and 3.97°. There is an offset face-to-face p-p stacking interaction between 1,3,4-oxadiazole ring planes. The compound molecules are connected through the offset face-to-face p-p stacking interactions to generate a three-dimensional network. The results of preliminary biological activity assay showed that the title compound exhibited good antibacterial activity against Staphylococcus aureus and Escherichia coli.

Keywords

Crystal structure Synthesis Antibacterial activity 1,3,4-Oxadiazole
Liu, X., & He, D. (2014). Synthesis, Crystal Structure and Antibacterial Activity of 2-(p-Tolyl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole. Asian Journal of Chemistry, 26(11), 3216–3218. https://doi.org/10.14233/ajchem.2014.15892
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