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Vol. 31 No. 10 (2019): Vol 31 Issue 10

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Synthesis and Spectral Investigations of Polymeric Hydrazone Schiff Base and its Transition Metal Complexes with Promising Antimicrobial, Anti-Angeogenic and DNA Photo-Cleavage Activities

https://doi.org/10.14233/ajchem.2019.22157
Manoj Kumar
Department of Chemistry, Maharishi Markandeshwar University, Sadopur, Ambala-134003, India
Anita Rani
Department of Chemistry, Maharishi Markandeshwar University, Sadopur, Ambala-134003, India
Hardeep Singh Tuli
Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala-133207, India
Rajshree Khare
Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala-133207, India
Vinit Parkash
Department of Chemistry, Maharishi Markandeshwar University, Sadopur, Ambala-134003, India

Corresponding Author(s) : Manoj Kumar

manojraju27@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 10 (2019): Vol 31 Issue 10

Abstract

This report describes the synthesis and exploration of novel Schiff base ligand in the form of a polymer (heptamer) which was prepared by reaction between 3,4-diacetyl-2,5-hexanedione and hydrazine hydrate in ethanol. On further reaction of Schiff base with transition metals ions (Co and Cu) leads to formation of its transition metal complexes. The structural identification of Schiff base ligand and its transition metal complexes were characterized by classical structural techniques like FT-IR, NMR and mass spectra. The free ligand and its transition metal complexes have been screened for in vitro biological activities against various strains of bacteria and fungi. The prepared Schiff base and its metal complexes were also screened for antiangiogenic activity. The results have shown the remarkable antimicrobial and antiangiogenic activities of the Schiff base and its metal complexes.

Keywords

3,4-Diacetyl-2,5-hexanedione Hydrazine hydrate Antimicrobial activity DNA-photocleavage
Kumar, M., Rani, A., Tuli, H. S., Khare, R., & Parkash, V. (2019). Synthesis and Spectral Investigations of Polymeric Hydrazone Schiff Base and its Transition Metal Complexes with Promising Antimicrobial, Anti-Angeogenic and DNA Photo-Cleavage Activities. Asian Journal of Chemistry, 31(10), 2331–2336. https://doi.org/10.14233/ajchem.2019.22157
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