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Novel MCR Synthesis of Post Transition Metal Complexes with Substituted Hydroxy Quinolines as Potent Antimicrobial Agent
Corresponding Author(s) : Ashhar Uz Zaman
Asian Journal of Chemistry,
Vol. 26 No. 12 (2014): Vol 26 Issue 12
Abstract
A series of Ni(II), Cu(II) and Zn(II) complexes have been synthesized by condensation and cyclization methodology. The ligand was synthesized by MCR (multi component reaction) of ortho toluidine, ethyl acetoacetate and triethyl ortho-formate and the condensed product was further cyclized in dowtherm A. The synthesized ligand was reacted with M(CH3COO)2 (M = Ni, Cu or Zn), to get complexes. The synthesized metal complexes and ligand were characterized by FT-IR, Mass, X-ray crystallography and atomic absorption. The ligand as well as metal complexes were also screened for antimicrobial activities. The data showed that complexes exhibited more biological activities than ligand.
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- M.C. Burla, R. Caliandro, M. Camalli, B. Carrozzini, G.L. Cascarano, L. De Caro, C. Giacovazzo, G. Polidori and R. Spagna, J. Appl. Cryst., 38, 381 (2005); doi:10.1107/S002188980403225X.
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- R.A. Chiarella, R.J. Davey and M.L. Peterson, Cryst. Growth Des., 7, 1223 (2007); doi:10.1021/cg070218y.
- A.A.A. Abu-Hussen and W. Linert, Synth. React. Inorg. Metal-Org. Nano-Metal Chem., 39, 13 (2009); doi:10.1080/15533170802668157.
- R. Rajavel, M.S. Vadivu and C. Anitha, E-J. Chem, 5, 620 (2008); doi:10.1155/2008/583487.
- H.I. Ugras, I. Basaran, T. Kilic and U. Cakir, J. Heterocycl. Chem., 43, 1679 (2006); doi:10.1002/jhet.5570430639.
- M. Pervaiz, M. Yousaf, A. Jabbar, A.F. Zahoor, T.H. Bokhari, A. Anjum, M. Sagir, M.A. Khan, K.G. Ali, S. Ahmad, M. Zia-ur-Rehman, S. Ashraf and K.S. Qeureshi, Asian J. Chem., 25, 2161 (2013); doi:10.14233/ajchem.2013.13374.
- D. Singh, K. Kumar, S.S. Dhiman and J. Sharma, J. Enzyme Inhib. Med. Chem., 25, 21 (2010); doi:10.3109/14756360902932750.
- P.G. Cozzi, Chem. Soc. Rev., 33, 410 (2004); doi:10.1039/b307853c.
- M. Yousaf, M. Pervaiz, A.F. Zahoor, A.I. Hussain, M.K.K. Khosa, S. Ashraf, M. Sagir, Ashar-uz-Zaman and K. Shehzad, Asian J. Chem., 25, 521 (2013); doi:10.14233/ajchem.2013.13412.
- F. Doğan, M. Ulusoy, Ö. Öztürk, İ. Kaya and B. Salih, J. Therm. Anal. Calorim., 98, 785 (2009); doi:10.1007/s10973-009-0205-2.
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References
M.C. Burla, R. Caliandro, M. Camalli, B. Carrozzini, G.L. Cascarano, L. De Caro, C. Giacovazzo, G. Polidori and R. Spagna, J. Appl. Cryst., 38, 381 (2005); doi:10.1107/S002188980403225X.
N. Sultana, A. Naz, M.S. Arayne and M.A. Mesaik, J. Mol. Struct., 969, 17 (2010); doi:10.1016/j.molstruc.2010.01.036.
R.A. Chiarella, R.J. Davey and M.L. Peterson, Cryst. Growth Des., 7, 1223 (2007); doi:10.1021/cg070218y.
A.A.A. Abu-Hussen and W. Linert, Synth. React. Inorg. Metal-Org. Nano-Metal Chem., 39, 13 (2009); doi:10.1080/15533170802668157.
R. Rajavel, M.S. Vadivu and C. Anitha, E-J. Chem, 5, 620 (2008); doi:10.1155/2008/583487.
H.I. Ugras, I. Basaran, T. Kilic and U. Cakir, J. Heterocycl. Chem., 43, 1679 (2006); doi:10.1002/jhet.5570430639.
M. Pervaiz, M. Yousaf, A. Jabbar, A.F. Zahoor, T.H. Bokhari, A. Anjum, M. Sagir, M.A. Khan, K.G. Ali, S. Ahmad, M. Zia-ur-Rehman, S. Ashraf and K.S. Qeureshi, Asian J. Chem., 25, 2161 (2013); doi:10.14233/ajchem.2013.13374.
D. Singh, K. Kumar, S.S. Dhiman and J. Sharma, J. Enzyme Inhib. Med. Chem., 25, 21 (2010); doi:10.3109/14756360902932750.
P.G. Cozzi, Chem. Soc. Rev., 33, 410 (2004); doi:10.1039/b307853c.
M. Yousaf, M. Pervaiz, A.F. Zahoor, A.I. Hussain, M.K.K. Khosa, S. Ashraf, M. Sagir, Ashar-uz-Zaman and K. Shehzad, Asian J. Chem., 25, 521 (2013); doi:10.14233/ajchem.2013.13412.
F. Doğan, M. Ulusoy, Ö. Öztürk, İ. Kaya and B. Salih, J. Therm. Anal. Calorim., 98, 785 (2009); doi:10.1007/s10973-009-0205-2.
M.F. Renehan, H.J. Schanz, E.M. McGarrigle, C.T. Dalton, A.M. Daly and D.G. Gilheany, J. Mol. Catal. Chem., 231, 205 (2005); doi:10.1016/j.molcata.2004.12.034.