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Synthesis, Characterization and in vitro Antimicrobial, Antioxidant and Anticancer Activity of Random Copolyester Using 1,4-Dithiane-2,5-diol
Corresponding Author(s) : B. Kalpana
Asian Journal of Chemistry,
Vol. 31 No. 10 (2019): Vol 31 Issue 10
Abstract
A random copolyester was prepared by direct melt polycondensation method using 1,4-dithiane-2,5-diol, 1,4-cyclohexane diol and Sebacic acid in the mole ratio 1:1:2 using titanium tetra isopropoxide as catalyst. The synthesized copolyester poly(1,4-dithiane-2,5-diol sebacate–co–1,4-cyclohexane diol sebacate) (PDCSe) was characterized by FT-IR, 1H NMR and 13C NMR to determine the chemical structure, while wide angle XRD, differential scanning spectroscopy and Inherent viscosity were determined to study its physical properties. Further the antioxidant, antimicrobial and anticancer activities of the synthesized copolyester were determined to study its biological property.
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References
T.S. Lu, Y.M. Sun and C.S. Wang, J. Polym. Sci., 33, 2841 (1995); https://doi.org/10.1002/pola.1995.080331618.
D. Byrom, Trends Biotechnol., 5, 246 (1987); https://doi.org/10.1016/0167-7799(87)90100-4.
J.M. Raquez, Y. Nabar, R. Narayan and P. Dubois, Macromol. Mater. Eng., 293, 310 (2008); https://doi.org/10.1002/mame.200700352.
B.D. Ulery, L.S. Nair and C.T. Laurencin, J. Polym. Sci., 49, 832 (2011); https://doi.org/10.1002/polb.22259.
H. Seyednejad, A.H. Ghassemi, C.F. van Nostrum, T. Vermonden and W.E. Hennink, J. Control. Rel., 152, 168 (2011); https://doi.org/10.1016/j.jconrel.2010.12.016.
M. Vert, Biomacromolecules, 6, 538 (2005); https://doi.org/10.1021/bm0494702.
A.K. Mohanty, M. Misra and G. Hinrichsen, Macromol. Mater. Eng., 276-277, 1 (2000); https://doi.org/10.1002/(SICI)1439-2054(20000301)276:1<1::AIDMAME1>3.0.CO;2-W.
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T. Okubo, S. Kohmoto, M. Yamamoto and T. Nakahira, J. Mater. Sci., 34, 337 (1999); https://doi.org/10.1023/A:1004417908638.
S. Kobayashi and H. Morijiri, Polymerizable Composition Containing Novel Cyclic Sulfur Compound and Resin Obtained by Curing the Polymerizable Composition, US Patent 7132501 B2 (2006).
G.B. Wayton, P. Trefonas III, S. Coley and T. Kurihara, Coating Compositions for Use with an Overcoated Photoresist, US Patent 6,852,421 B2 (2005).
H. Yao and S.S. Ding-Lee, Organic Bottom Anti Reflective Polymer Compositions, US Patent 7470500B2 (2008).
W. Klauck, J. Klein, L. Duhm, W. Maler, Cyanacrylate Adhesive with Ester and Polymer Additives, US Patent 6617385B1 (2001).
F. Zamberlan, A. Fantinati and C. Trapella, Eur. J. Org. Chem., 3248 (2018); https://doi.org/10.1002/ejoc.201701785.
S. Vivek Kumar, S. Muthusubramanian, J. Carlos-Menendez and S. Perumal, Beilstein J. Org. Chem., 11, 1707 (2015); https://doi.org/10.3762/bjoc.11.185.
C.E. Stephens, T.M. Felder and J.W. Sr, Bioorg. Med. Chem., 9, 1123 (2001); https://doi.org/10.1016/S0968-0896(00)00333-3.
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W. Beerheide, H.-U. Bernard, Y.-J. Tan, A. Ganesan, W.G. Rice and A.E. Ting, J. Natl. Cancer Inst., 91, 1211 (1999); https://doi.org/10.1093/jnci/91.14.1211.
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C.C. Garcia, N.A. Candurra and E.B. Damonte, Antiviral Chem. Chemother., 11, 231 (2000); https://doi.org/10.1177/095632020001100306.
J.A. Stammen, S. Williams, D.N. Ku and R.E. Guldberg, Biomaterials, 22, 799 (2001); https://doi.org/10.1016/S0142-9612(00)00242-8.