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Biodistribution of Uranium in Mice and Influencing Factor Preliminary Discussion
Corresponding Author(s) : Deng Bing
Asian Journal of Chemistry,
Vol. 26 No. 13 (2014): Vol 26 Issue 13
Abstract
The general objective of our work was to preliminary discuss the relationship between uranium(VI) distribution in mice and the speciation of uranium in blood plasma and urine. The results show that, mice were injected with depleted uranium (DU) (5 mg/kg), the important uranium deposit sites are bones, kidneys, liver and spleen. Excretion of uranium mainly through kidney and the concentration of uranium in the liver and spleen have two peaks with time passed. Computer simulation shows that the major uranium species were uranium complex ions at normal blood plasma pH value, which explain the animal experiment phenomenon that uranium removed faster in the blood and the species of uranium in the plasma blood related to the total uranium concentration. The formation of souble uranyl ion with phosphate radical is high solubility solid material, resulting in uranium long-term deposition in bone. Computer simulation also shows the solid phase as (UO2)3(PO4)2·4H2O appeared in the urine, which are toxic to kidneys.
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- A. Bleise, P.R. Danesi and W. Burkart, J. Environ. Radioact., 64, 93 (2003); doi:10.1016/S0265-931X(02)00041-3.
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- S. Chevari and D. Likhner, J. Inorg. Chem., 13, 8 (1968).
- P. Kurttio, H. Komulainen and A. Leino, J. Environ. Health Perspect., 113, 1 (2005).
- W.F. Neuman, R.W. Fleming and A.L. Dounce, J. Biol. Chem., 173, 737 (1948).
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References
A. Bleise, P.R. Danesi and W. Burkart, J. Environ. Radioact., 64, 93 (2003); doi:10.1016/S0265-931X(02)00041-3.
E. Craft, A. Abu-Qare, M. Flaherty, M. Garofolo, H. Rincavage and M. Abou-Donia, J. Toxicol. Environ. Health B Crit. Rev., 7, 297 (2004); doi:10.1080/10937400490452714.
R. Hindin, D. Brugge and B. Panikkar, J. Environ. Health, 4, 17 (2005); doi:10.1186/1476-069X-4-17.
Environmental monitoring and personnel protection in uranium processing. In Handbook of Experimental Pharmacologys Uranium, Plutonium, Transplutonic Elements, H. C. Hodge, J. N. Stannard, and J. B. Hursh, Eds. Springer-Verlag, New York, p.271.
K. Yapar, K. Cavusoglu, E. Oruc and E. Yalcin, J. Med. Food, 13, 179 (2010); doi:10.1089/jmf.2009.0028.
D.E. McClain, K.A. Benson, T.K. Dalton, J. Ejnik, C.A. Emond, S.J. Hodge, J.F. Kalinich, M.A. Landauer, A.C. Miller, T.C. Pellmar, M.D. Stewart, V. Villa and J. Xu, J. Sci Total Environ., 274, 115 (2001); doi:10.1016/S0048-9697(01)00734-3.
M. Sutton and S.R. Burastero, J. Chem. Res. Toxicol., 16, 1145 (2003); doi:10.1021/tx0256477.
Y. Hao, R. Li, Y. Leng, J. Ren, J. Liu, G. Ai, H. Xu, Y. Su and T. Cheng, J. Radiat. Res. (Tokyo), 50, 521 (2009); doi:10.1269/jrr.09052.
J.D. Allison, K.J. Novo-Gradac and D.S. Brown, MINTEQA2 Version 4sA Geochemical Assessment Model for Environmental Systems, Environmental Research Laboratory, Office of Research & Development, United States Environmental Protection Agency, Athens, Georgia (1998).
R.M. Smith and A.E. Martell, 1982 Critical Stability Constants, Vol. 5, Plenum Press, NewYork.
R.J. Motekaitis, 2001 NIST Standard Reference Database 46 version 6. NIST Critically Selected Stability Constants of Metal Complexes (Martell, A. E., and Smith, R. M., Eds.) National Institute of Standards and Technology (NIST), Gaithersburg, MD.
I. Grenthe, J. Fuger, R.J.M. Konings, R.J. Lemire, A.B. Muller, C. Nguyen-Trung and H. Wanner, 1992 Chemical Thermodynamics of Uranium, Nuclear Energy Agency, Elsevier, Holland; Updated 2003.
A.C. Guyton and J.E. Hall, Textbook of Medical Physiology, W.B. Saunders Company, Philadelphia (2000).
G.V. Iyengar and W.E. Kollmer, J. Verlag Chemic., 31, 39 (1978).
S. Scapolan, E. Ansoborlo, C. Moulin and C. Madic, J. Alloy. Comp., 271, 106 (1998); doi:10.1016/S0925-8388(98)00035-8.
S. Chevari and D. Likhner, J. Inorg. Chem., 13, 8 (1968).
P. Kurttio, H. Komulainen and A. Leino, J. Environ. Health Perspect., 113, 1 (2005).
W.F. Neuman, R.W. Fleming and A.L. Dounce, J. Biol. Chem., 173, 737 (1948).
D. Ribera, F. Labrot, G. Tisnerat and J.F. Narbonne, J. Rev. Environ. Contam. Toxicol., 146, 53 (1996); doi:10.1007/978-1-4613-8478-6_3.
A.L. Dounce, C. Voegthin and H.C. Hodge, “Pharmacology and Toxicology of uranium compounds”, ed.1949, Mc Graw-Hill, New York, 951.
S. Homma-Takeda, Y. Terada, A. Nakata, S.K. Sahoo, S. Yoshida, S. Ueno, M. Inoue, H. Iso, T. Ishikawa, T. Konishi, H. Imaseki and Y. Shimada, J. Nuclear Instruments Methods in Physics Research, 15, 267 (2009); doi:10.1016/j.nimb.2009.03.082.
J.J. Morrissey and S. Klahr, J. Kidney Int, 52, 4 (1997).