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Vol. 31 No. 12 (2019): Vol 31 Issue 12

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Synthesis, Molecular Docking and Antimicrobial Studies of Some Novel 1,4-Dihydropyridine Derivatives

https://doi.org/10.14233/ajchem.2019.22330
D. Ashokkumar
Department of Chemistry, Annamalai University, Annamalai Nagar-608 002, India
G. Ramalingam
Department of Chemistry, Annamalai University, Annamalai Nagar-608 002, India
M. Gopalakrishnan
Department of Chemistry, Annamalai University, Annamalai Nagar-608 002, India

Corresponding Author(s) : G. Ramalingam

drgr_dde@rediffmail.com

Asian Journal of Chemistry, Vol. 31 No. 12 (2019): Vol 31 Issue 12

Abstract

Three components one pot synthesis of some novel triazole substituted 1,4-dihydropyridine compounds from the simple condensation reaction of ethyl acetoacetate, 4-amino triazole and aromatic aldehyde has been demonstrated using on low cost and efficient acetic acid catalyst in solvent free condition followed by microwave irradiation method. The newly synthesized 1,4-dihydropyridine compounds exhibit in excellent yield. The synthesized dihydropyridine derivatives are screened for antimicrobial properties and molecular docking study.

Keywords

Triazole 1,4-Dihydropyridine Microwave irradiation Antimicrobial activities Molecular docking
Ashokkumar, D., Ramalingam, G., & Gopalakrishnan, M. (2019). Synthesis, Molecular Docking and Antimicrobial Studies of Some Novel 1,4-Dihydropyridine Derivatives. Asian Journal of Chemistry, 31(12), 2976–2980. https://doi.org/10.14233/ajchem.2019.22330
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