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Vol. 31 No. 10 (2019): Vol 31 Issue 10

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A Concise and Efficient Synthesis of an Impurity, N-Desmethyl Alcaftadine from Alcaftadine: An H1 Antagonist

https://doi.org/10.14233/ajchem.2019.22059
G. Sravya
Ural Federal University, Chemical Engineering Institute, Yekaterinburg 620002, Russia
https://orcid.org/0000-0002-6249-3870
Grigory V. Zyryanov
Ural Federal University, Chemical Engineering Institute, Yekaterinburg 620002, Russia & I. Ya. Postovskiy Institute of Organic Synthesis, Ural Division of the Russian Academy of Sciences, Yekaterinburg 620219, Russia
K. Ramaseshaiah
Rajeev Gandhi Memorial College of Engineering and Technology (Autonomous), Nandyal-518501, India & Department of Chemistry, Krishna University, Machilipatnam-521001, India
G. Malli Karjuna Reddy
Ural Federal University, Chemical Engineering Institute, Yekaterinburg 620002, Russia
C. Suresh Reddy
Department of Chemistry, Sri Venkateswara University, Tirupati-517502, India
https://orcid.org/0000-0002-9804-9683
N. Bakthavatchala Reddy
Ural Federal University, Chemical Engineering Institute, Yekaterinburg 620002, Russia
https://orcid.org/0000-0003-2039-9277

Corresponding Author(s) : N. Bakthavatchala Reddy

drbvreddyn@gmail.com

Asian Journal of Chemistry, Vol. 31 No. 10 (2019): Vol 31 Issue 10

Abstract

Herein, a simple approach for the synthesis of N-desmethyl alcaftadine, an H1 histamine antagonist in solid state and its structure is presented. The reactions were performed under mild and metal free conditions at reflux temperature within a range of 65-70 ºC and the desired product N-desmethyl alcaftadine was obtained in high purity with good yield (96.42 %). It was detected by ultra-high-performance liquid chromatography (UHPLC).

Keywords

Antihistamine Alcaftadine N-Desmethyl Alcaftadine
Sravya, G., Zyryanov, G. V., Ramaseshaiah, K., Karjuna Reddy, G. M., Reddy, C. S., & Reddy, N. B. (2019). A Concise and Efficient Synthesis of an Impurity, N-Desmethyl Alcaftadine from Alcaftadine: An H1 Antagonist. Asian Journal of Chemistry, 31(10), 2257–2260. https://doi.org/10.14233/ajchem.2019.22059
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