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Vol. 26 No. 14 (2014): Vol 26 Issue 14

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Biological Interaction Between Copper(II) Complex and Nucleosides

https://doi.org/10.14233/ajchem.2014.16964
Yaping Guo
Department of Chemistry, Sanquan College of Xinxiang Medical University, Jinsui Road 601, Xinxiang 453003, Henan Province, P.R. China
Xiuju Wang
Department of Chemistry, Sanquan College of Xinxiang Medical University, Jinsui Road 601, Xinxiang 453003, Henan Province, P.R. China
Leiming Luo
Department of Pharmacy, Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China
Jinge Du
Department of Chemistry, Sanquan College of Xinxiang Medical University, Jinsui Road 601, Xinxiang 453003, Henan Province, P.R. China
Xuefang Shang
Department of Chemistry, Xinxiang Medical University, Jinsui Road 601, Xinxiang 453003, Henan Province, P.R. China

Corresponding Author(s) : Xuefang Shang

xuefangshang@126.com; gypapply@163.com

Asian Journal of Chemistry, Vol. 26 No. 14 (2014): Vol 26 Issue 14

Abstract

A copper-coordinated complex based on 7-membered amide cycle has been designed and synthesized. Its binding properties for various nucleosides, guanosine-5'-diphosphate (GDP), uridine-5'-diphosphate (UDP), inosine-5'- diphosphate (IDP) and guanosine-5'-triphosphate (GTP) has been studied by UV-visible spectra and crystal structure. Results indicated that the compound showed the highest binding ability with guanosine-5'-triphosphate in water solution among the studied nucleosides. The interaction of host-guest derived from hydrogen bonding and p-p staking and the host-guest binding ability depended on the chain length of nucleosides. In addition, the compound can be used to label nucleoside.

Keywords

Biological interaction Nucleoside Copper (II) complex
Guo, Y., Wang, X., Luo, L., Du, J., & Shang, X. (2014). Biological Interaction Between Copper(II) Complex and Nucleosides. Asian Journal of Chemistry, 26(14), 4457–4461. https://doi.org/10.14233/ajchem.2014.16964
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