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Vol. 26 No. 14 (2014): Vol 26 Issue 14

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Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine

https://doi.org/10.14233/ajchem.2014.16756
Ibrahim E. El-Shamy
Chemistry Department, Faculty of Science, Fayoum University, Fayoum, Egypt
A.M. Abdel-Mohsen
Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic; Textile Research Division, National Research Center, Dokki, Giza, P.O. 12622, Giza 12522, Egypt
Moustafa M.G. Fouda
Petrochemical Research Chair, Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Salem S. Al-Deyab
Petrochemical Research Chair, Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Maher A. El-Hashash
Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt

Corresponding Author(s) : Ibrahim E. El-Shamy

iei00@fayoum.edu.eg

Asian Journal of Chemistry, Vol. 26 No. 14 (2014): Vol 26 Issue 14

Abstract

1-Chloro-4-(2,4,6-trimethylphenyl)phthalazine (2) was used as a precursor for preparation of some novel pyrazolylphthalazine derivatives 6-13 and 15-19. Moreover, the acyclonucleosides 20-23 a-e were prepared by the reaction of hydrazinophthalazine derivative 3 with different aldoses. All new phthalazine derivatives were characterized using 1H NMR, 13C NMR, FTIR, mass spectrum and elemental analysis. The newly synthesized compounds showed highly activity against different species of bacteria and fungi, in addition to an excellent antiinflammatory property.

Keywords

C-nucleosides Phthalazine derivatives Biological activity
E. El-Shamy, I., Abdel-Mohsen, A., M.G. Fouda, M., S. Al-Deyab, S., & A. El-Hashash, M. (2014). Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine. Asian Journal of Chemistry, 26(14), 4405–4415. https://doi.org/10.14233/ajchem.2014.16756
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Author Biography

A.M. Abdel-Mohsen, Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic; Textile Research Division, National Research Center, Dokki, Giza, P.O. 12622, Giza 12522, Egypt

 

 

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