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Antiinflammatory and Analgesic Activities of Different Fractions of Populus tomentosa Carr. Leaves
Corresponding Author(s) : Xueyan Fu
Asian Journal of Chemistry,
Vol. 26 No. 15 (2014): Vol 26 Issue 15
Abstract
The antiinflammatory and analgesic properties of different polar fractions of Populus tomentosa leaves were investigated in mice. The analgesic activities of leaf extracts were evaluated with hot-plate and acetic acid writhing tests. Anti-inflammatory effects were studied using xylene-induced ear edema and egg albumen-induced paw edema. Low dose (1 g/kg) and high dose (3 g/kg) aqueous extracts had significant analgesic effects (p < 0.05) for the acetic acid writhing test. High doses of ethanol (3 g/kg), petroleum ether (0.5 g/kg) and butanol extracts (0.5 g/kg) prolonged hot-plate reaction times (p < 0.05) and had better analgesia. Petroleum ether extract (0.5 g/kg) was better than controls for reducing xylene-induced ear edema (p < 0.05). Low doses of aqueous (1 g/kg), ethyl acetate (0.5 g/kg) and butanol extracts (0.5 g/kg) reduced foot swelling due to egg albumen better than controls (p < 0.05). These findings indicate that water and ethanol extracts, as well as different ethanol polarity fractions, from Populus tomentosa leaves have analgesic and anti-inflammatory effects which are consistent with their use in traditional medicine.
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References
M. Lin and S.Z. Li, Yao Xue Xue Bao, 28, 437 (1993).
X.L. Du and F.Q. Xue, Northwest Pharm. J., 11, 86 (1996).
X.-Z. Yang, Inner Mongolia J. Tradit. Chinese Med., vol. 10 (1987).
G.Z. Li and Z.G. Tao, Shanxi J. Tradit. Chinese Med., 5, 45 (1985).
Family Nurse, 2006
Heilong jiang Animal Husbandry and Veternary Guide edition (2012).
F.-W. Li, Study on Compounds of Populus Tomentosacarr, Shandong Agricultural University, Tai'an, pp. 5-6 (2005).
Chinese Veterinary Science, 2006
Chinese Journal of Clinical Pharmacology and Therapeutics (2012).
T.B. Ma, M.G. Li and J.L. Li, Chin. Tradit. Herbal Drugs, 15, 9 (1957).
R. Koster, M. Anderson and E.J. De Beer, Acetic acid for analgesic screening. In: Federation Proceedings, p. 412 (1959).
D.H. Dang, M.H. Hoang, M.T. Nguyen, V.M. Chau and T.T.H. Nguyen, Vietnam J. Chem., 46, 81 (2008).
H.G. Vogel, Drug Discovery and Evaluation, Springer (2002).
D. Le Bars, M. Gozariu and S.W. Cadden, Pharmacol. Rev., 53, 597 (2001).
G.A. Bentley, S.H. Newton and J. Starr, Br. J. Pharmacol., 73, 325 (1981); doi:10.1111/j.1476-5381.1981.tb10425.x.
A. Mandegary, M. Sayyah, M. Kamalinejad and M.R. Heidari, Daru, 12, 58 (2004).
J. Parkhouse and B.J. Parkhouse, Analgesics Drugs. Blackwell Co, Traditional Chinese Herbal Medicine of Information Center of the State Administration, Handbook of Plant Effective Constituent. People's Health Publishing House, Beijing (1979).