A New Xanthone from the Fermentation Products of Endophytic Fungus of Phomopsis Species

Yuchun Yang; Haiyin Yang; Yinke Li; Yanqing Ye; Qiufen Hu; Xuemei Gao; Gang Du

doi:10.14233/ajchem.2014.1612

Issue

Vol. 26 No. 15 (2014): Vol 26 Issue 15

Issue Published : July 16, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

A New Xanthone from the Fermentation Products of Endophytic Fungus of Phomopsis Species

https://doi.org/10.14233/ajchem.2014.1612

Yuchun Yang

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Haiyin Yang

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Yinke Li

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China; Collge of Resource and Environment, Yuxi Normal University, Yuxi 653100, P.R. China

Yanqing Ye

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Qiufen Hu

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Xuemei Gao

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Gang Du

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Corresponding Author(s) : Gang Du

dugang2006@aliyun.com

Asian Journal of Chemistry, Vol. 26 No. 15 (2014): Vol 26 Issue 15
Article Published : July 16, 2014

Abstract

A new xanthone, 1,3-dihydroxy-4-(1,3,4-trihydroxybutan-2-yl)-8-methoxy-9H-xanthen-9-one (1) was isolated from the fermentation products of a Phomopsis fungus. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D- NMR techniques. Compound 1 was also evaluated for their cytotoxicity against five human tumor cell lines and it showed high cytotoxicity against A549 and PC3 cell with IC₅₀ values of 5.8 and 3.6 μM, respectively.

Keywords

Xanthone Fermentation Phomopsis Endophytic

Yang, Y., Yang, H., Li, Y., Ye, Y., Hu, Q., Gao, X., & Du, G. (2014). A New Xanthone from the Fermentation Products of Endophytic Fungus of Phomopsis Species. Asian Journal of Chemistry, 26(15), 4591–4593. https://doi.org/10.14233/ajchem.2014.1612

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References

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References

D. Udayanga, X. Liu, E.H.C. McKenzie, E. Chukeatirote, A.H.A. Bahkali and K.D. Hyde, Fungal Divers., 50, 189 (2011); doi:10.1007/s13225-011-0126-9.

J.N. Choi, J. Kim, K. Ponnusamy, C. Lim, J.G. Kim, M.J. Muthaiya and C.H. Lee, J. Antibiot., 66, 231 (2013); doi:10.1038/ja.2012.105.

H. Hussain, M.K. Tchimene, I.K. Ahmed, M. Steinert, S. Draeger, B. Schulz and K. Krohn, Nat. Prod. Commun., 6, 1905 (2011).

H. Hussain, I. Ahmed, B. Schulz, S. Draeger and K. Krohn, Fitoterapia, 83, 523 (2012); doi:10.1016/j.fitote.2011.12.017.

H. Hussain, K. Krohn, I. Ahmed, S. Draeger, B. Schulz, S. Di Pietro and G. Pescitelli, Eur. J. Org. Chem., 2012, 1783 (2012); doi:10.1002/ejoc.201101788.

M. Isaka, A. Jaturapat, K. Rukseree, K. Danwisetkanjana, M. Tanticharoen and Y. Thebtaranonth, J. Nat. Prod., 64, 1015 (2001); doi:10.1021/np010006h.

C. Hemtasin, S. Kanokmedhakul, K. Kanokmedhakul, C. Hahnvajanawong, K. Soytong, S. Prabpai and P. Kongsaeree, J. Nat. Prod., 74, 609 (2011); doi:10.1021/np100632g.

E. Adelin, C. Servy, S. Cortial, H. Lévaique, M.-T. Martin, P. Retailleau, G. Le Goff, B. Bussaban, S. Lumyong and J. Ouazzani, Phytochemistry, 72, 2406 (2011); doi:10.1016/j.phytochem.2011.08.010.

C. Hemtasin, S. Kanokmedhakul, K. Kanokmedhakul, C. Hahnvajanawong, K. Soytong, S. Prabpai and P. Kongsaeree, J. Nat. Prod., 74, 609 (2011); doi:10.1021/np100632g.

K.S. Masters and S. Brase, Chem. Rev., 112, 3717 (2012); doi:10.1021/cr100446h.

S. Kaul, S. Gupta, M. Ahmed and M.K. Dhar, Phytochem. Rev., 11, 487 (2012); doi:10.1007/s11101-012-9260-6.

F. Zhu and Y.C. Lin, Chem. Nat. Comp., 43, 132 (2007); doi:10.1007/s10600-007-0062-9.

M. Isaka, A. Jaturapat, K. Rukseree, K. Danwisetkanjana, M. Tanticharoen and Y. Thebtaranonth, J. Nat. Prod., 64, 1015 (2001); doi:10.1021/np010006h.

J.X. Yang, S.X. Qiu, Z.G. She and Y.C. Lin, Chem. Nat. Comp., 49, 31 (2013); doi:10.1007/s10600-013-0498-z.

X.M. Gao, R.R. Wang, D.Y. Niu, C.Y. Meng, L.M. Yang, Y.T. Zheng, G.Y. Yang, Q.F. Hu, H.D. Sun and W.L. Xiao, J. Nat. Prod., 76, 1052 (2013); doi:10.1021/np400070x.

Issue

Vol. 26 No. 15 (2014): Vol 26 Issue 15

A New Xanthone from the Fermentation Products of Endophytic Fungus of Phomopsis Species

Corresponding Author(s) : Gang Du

Abstract

Keywords

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