Antimicrobial Evaluation and Crystal Structure of Parthenolide from Tarconanthus camphoratus Collected in Saudi Arabia

Wadah Jamal; Ahmed Bari; Ramzi A. Mothana; Omer Basudan; Mona S. Mohammed; S.W. Ng

doi:10.14233/ajchem.2014.16653

Issue

Vol. 26 No. 16 (2014): Vol 26 Issue 16

Issue Published : July 28, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Antimicrobial Evaluation and Crystal Structure of Parthenolide from Tarconanthus camphoratus Collected in Saudi Arabia

https://doi.org/10.14233/ajchem.2014.16653

Wadah Jamal

Department of Pharmacognosy, University of Khartoum, P.O. Box 321, Khartoum, Sudan

Ahmed Bari

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia

Ramzi A. Mothana

Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia

Omer Basudan

Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia

Mona S. Mohammed

Department of Pharmacognosy, University of Khartoum, P.O. Box 321, Khartoum, Sudan

S.W. Ng

Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia

Corresponding Author(s) : Ahmed Bari

abari@ksu.edu.sa

Asian Journal of Chemistry, Vol. 26 No. 16 (2014): Vol 26 Issue 16
Article Published : August 4, 2014

Abstract

Tarconanthus camphoratus is a perennial traditional medicinal herb and is a rich source of sesquiterpene lactones called parthenolides. 4xi-Germacra-1(10)-11(13)-dien-12-oic-acid-4,5-epoxy-6a-hydroxy-g-lactone (parthenolide) contains both an a-methylene-g-lactone ring and an epoxide group, which interact with the nucleophilic sites of many biological molecules. Here in, we reported the crystal structure in vitro antimicrobial activities and MIC evaluation of parthenolide isolated from Saudi Arabian plant.

Keywords

Parthenolide Anti-microbial Sesquiterpene lactone Anti-inflammatery Asteraceae

Jamal, W., Bari, A., A. Mothana, R., Basudan, O., S. Mohammed, M., & Ng, S. (2014). Antimicrobial Evaluation and Crystal Structure of Parthenolide from Tarconanthus camphoratus Collected in Saudi Arabia. Asian Journal of Chemistry, 26(16), 5183–5185. https://doi.org/10.14233/ajchem.2014.16653

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References

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References

A.M. Brown, C.M. Edwards, M.R. Davey, J.B. Power and K.C. Lowe, J. Pharm. Pharmacol., 49, 558 (1997); doi:10.1111/j.2042-7158.1997.tb06841.x.

S.P. Hehner, T.G. Hofmann, W. Dröge and M.L. Schmitz, J. Immunol., 163, 5617 (1999).

D.W. Knight, Nat. Prod. Rep., 12, 271 (1995); doi:10.1039/np9951200271.

B.H. Kwok, B. Koh, M.I. Ndubuisi, M. Elofsson and C.M. Crews, Chem. Biol., 8, 759 (2001); doi:10.1016/S1074-5521(01)00049-7.

H. Nakshatri, S.E. Rice and P. Bhat-Nakshatri, Oncogene, 23, 7330 (2004); doi:10.1038/sj.onc.1207995.

J.J. Ross, J.T. Arnason and H.C. Birnboim, Planta Med., 65, 126 (1999); doi:10.1055/s-1999-13972.

J. Wen, K.R. You, S.Y. Lee, C.H. Song and D.G. Kim, J. Biol. Chem., 277, 38954 (2002); doi:10.1074/jbc.M203842200.

J.M. Woynarowski and J. Konopa, Mol. Pharmacol., 19, 97 (1981).

Q. Zhang, Y. Lu, Y. Ding, J. Zhai, Q. Ji, W. Ma, M. Yang, H. Fan, J. Long, Z. Tong, Y. Shi, Y. Jia, B. Han, W. Zhang, C. Qiu, X. Ma, Q. Li, Q. Shi, H. Zhang, D. Li, J. Zhang, J. Lin, L.-Y. Li, Y. Gao and Y. Chen, J. Med. Chem., 55, 8757 (2012); doi:10.1021/jm301064b.

S. Collenette, An Illustrated Guide to the Flowers of Saudi Arabia; Scorpion: London, p. 283 (1985).

M.A. Al-Yahya, I.A. Al-Meshal, J.S. Mossa, A.A. Al-Badr and M. Tariq, Saudi Plants: A Phytochemical and Biological Approach; King Abdul Aziz City for Science & Technology (KACST): Riyadh, pp. 32-34 (1990).

M. Majdi, Q. Liu, G. Karimzadeh, M.A. Malboobi, J. Beekwilder, K. Cankar, R. Vos, S. Todorović, A. Simonović and H. Bouwmeester, Phytochemistry, 72, 1739 (2011); doi:10.1016/j.phytochem.2011.04.021.

D.V.C. Awang, B.A. Dawson, D.G. Kindack, C.W. Crompton and S. Heptinstall, J. Nat. Prod., 54, 1516 (1991); doi:10.1021/np50078a005.

Y.L. Nene and P.N. Thapliyal, Fungicides in Plant Disease Control, IBH, New Delhi, India (1982).

Issue

Vol. 26 No. 16 (2014): Vol 26 Issue 16

Antimicrobial Evaluation and Crystal Structure of Parthenolide from Tarconanthus camphoratus Collected in Saudi Arabia

Corresponding Author(s) : Ahmed Bari

Abstract

Keywords

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