Synthesis and Antimicrobial Evaluation of 2-Aminobenzophenone Linked 1,4-Dihydropyridine Derivatives

Pengying Li; Ketki Sahore; Jianjun Liu; Rajesh K. Singh

doi:10.14233/ajchem.2014.17403

Issue

Vol. 26 No. 16 (2014): Vol 26 Issue 16

Issue Published : July 28, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Antimicrobial Evaluation of 2-Aminobenzophenone Linked 1,4-Dihydropyridine Derivatives

https://doi.org/10.14233/ajchem.2014.17403

Pengying Li

Forestry College, Northwest A and F University, Yangling 712100, P.R. China

Ketki Sahore

Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy (Under Local Govt. Dept. Punjab) Nangal, Distt. Rupnagar-140126, Punjab, India

Jianjun Liu

Forestry College, Northwest A and F University, Yangling 712100, P.R. China

Rajesh K. Singh

Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy (Under Local Govt. Dept. Punjab) Nangal, Distt. Rupnagar-140126, Punjab, India

Corresponding Author(s) : Jianjun Liu

jianjun2013Liu@126.com

Asian Journal of Chemistry, Vol. 26 No. 16 (2014): Vol 26 Issue 16
Article Published : August 4, 2014

Abstract

A series of novel aminobenzophenone linked 1,4-dihydropyridines (1,4-DHPs) hybrids were synthesized by incorporating aminobenzophenone moiety on 1,4-dihydropyridines scaffold (5a-f) and characterized by IR, ¹H NMR and CHN elemental analysis. The synthesized compounds were tested for their in vitro antibacterial activity against the Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. Among all the synthesized compounds, compounds 5b, 5c and 5e have shown the maximum activity in their group whereas compounds 5a, 5d, 5f have shown the minimum activity.

Keywords

Pharmacophore 1,4-Dihydropyridine 2-Aminobenzophenone Antimicrobial activity

Li, P., Sahore, K., Liu, J., & K. Singh, R. (2014). Synthesis and Antimicrobial Evaluation of 2-Aminobenzophenone Linked 1,4-Dihydropyridine Derivatives. Asian Journal of Chemistry, 26(16), 5291–5294. https://doi.org/10.14233/ajchem.2014.17403

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References

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V. Niraimathi, A.J. Suresh, S. Latha and S.C. Bala, Int. J. Pharm. Pharm. Sci., 4, 212 (2012).
D.A. Walsh, Synthesis, 677 (1980); doi:10.1055/s-1980-29169.
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P. Cheng, Q. Zhang, Y-B. Ma, Z-Y. Jiang, X. M. Zhang, F.X. Zhang and J.J. Chen, Bioorg. Med. Chem. Lett., 18, 3787 (2008).
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Indian Pharmacopoeia, Government of India, Ministry of Health and Welfare, Published by Controller of publication, New Delhi, II, A105 (1996).

References

R.R. Poondra, R.V. Nallamelli, C.L.T. Meda, B.N.V. Srinivas, A. Grover, J. Muttabathula, S.R. Voleti, B. Sridhar, M. Pal and K.V.L. Parsa, Bioorg. Med. Chem. Lett., 23, 1104 (2013); doi:10.1016/j.bmcl.2012.11.121.

R. Boer and V. Gekeler, Drugs Future, 20, 499 (1995).

V.M. Briukhanov, Exp. Clin. Pharmacol., 57, 47 (1994).

S. Gullapalli and P. Ramarao, Neuropharmacology, 42, 467 (2002); doi:10.1016/S0028-3908(01)00200-3.

S. Bahekar and D. Shinde, Acta Pharm., 52, 281 (2002).

R. León, C. Ríos, J. Marco-Contelles, O. Huertas, X. Barril, F. Javier Luque, M.G. López, A.G. García and M. Villarroya, Bioorg. Med. Chem., 16, 7759 (2008); doi:10.1016/j.bmc.2008.07.005.

J. Marco-Contelles, R. León, C.de los Ríos, A. Samadi, M. Bartolini, V. Andrisano, O. Huertas, X. Barril, F.J. Luque, M.I. Rodríguez-Franco, B. López, M.G. López, A.G. García, M. do Carmo Carreiras and M. Villarroya, J. Med. Chem., 52, 2724 (2009); doi:10.1021/jm801292b.

S.Ulloora, R.Shabaraya, R.Ranganathan and A.V.Adhikari, Eur. J. Med. Chem., 70, 341 (2013); doi:10.1016/j.ejmech.2013.10.010.

G.A. Wachter, M.C. Davis, A.R. Martin and S.G. Franzblau, J. Med. Chem., 41, 2436 (1998); doi:10.1021/jm9708745.

V.L.R. Sana, V.R. Katla, S. Chennamsetty, A. Shaik and N.R. Chamarthi, Der Pharm. Sinica, 4, 10 (2013).

A.M. Vijesh, A.M. Isloor, S.K. Peethambar, K.N. Shivananda, T. Arulmoli and N.A. Isloor, Eur. J. Med. Chem., 46, 5591 (2011); doi:10.1016/j.ejmech.2011.09.026.

Y.L.N. Murthy, A. Rajack, M.T. Ramji, J. Jesonbabu, C. Praveen and K.A. Lakshmi, Bioorg. Med. Chem. Lett., 22, 6016 (2012); doi:10.1016/j.bmcl.2012.05.003.

V. Niraimathi, A.J. Suresh, S. Latha and S.C. Bala, Int. J. Pharm. Pharm. Sci., 4, 212 (2012).

D.A. Walsh, Synthesis, 677 (1980); doi:10.1055/s-1980-29169.

E.R. Ottosen, M.D. Sørensen, F. Björkling, T. Skak-Nielsen, M.S. Fjording, H. Aaes and L. Binderup, J. Med. Chem., 46, 5651 (2003); doi:10.1021/jm030851s.

S. Cortez-Maya, E. Cortes, S. Hernández-Ortega, T. Ramirez Apan and M. Martínez-García, Synth. Commun., 42, 46 (2012); doi:10.1080/00397911.2010.521435.

J.P. Liou, C.W. Chang, J.S. Song, Y.N. Yang, C.F. Yeh, H.Y. Tseng, Y.K. Lo, Y.L. Chang, C.M. Chang and H.P. Hsieh, J. Med. Chem., 45, 2556 (2002); doi:10.1021/jm010365+.

P. Cheng, Q. Zhang, Y-B. Ma, Z-Y. Jiang, X. M. Zhang, F.X. Zhang and J.J. Chen, Bioorg. Med. Chem. Lett., 18, 3787 (2008).

R.K. Singh, S. Devi and D.N. Prasad, Arab. J. Chem., doi:10.1016/j.arabjc.2011.11.013.

L. Sun, J. Wu, M. Luo, X. Wang, M. Pan, Z. Gou and D. Sun, Molecules, 16, 9739 (2011); doi:10.3390/molecules16119739.

A. Sakunpak and P. Panichayupakaranant, Food Chem., 130, 826 (2012); doi:10.1016/j.foodchem.2011.07.088.

P. Kaur, H. Sharma, R. Rana, D.N. Prasad and R.K. Singh, Asian J. Chem., 24, 5649 (2012).

P. Kaur and R.K. Singh, Chem. Sci. Trans, 2(S1), S295 (2013); doi:10.7598/cst2013.443.

Indian Pharmacopoeia, Government of India, Ministry of Health and Welfare, Published by Controller of publication, New Delhi, II, A105 (1996).

Issue

Vol. 26 No. 16 (2014): Vol 26 Issue 16

Synthesis and Antimicrobial Evaluation of 2-Aminobenzophenone Linked 1,4-Dihydropyridine Derivatives

Corresponding Author(s) : Jianjun Liu

Abstract

Keywords

Full Article

Download Citation

References

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