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Vol. 37 No. 9 (2025): Vol 37 Issue 9, 2025

Copyright (c) 2025 Ranajit Kumar Sutradhar, Sadia Sultana, Priya Barua, Md. Din Islam

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Bioactivity Screening and in silico Studies of Phenyl Thiazole Derivatives Containing Arylidene Moieties

https://doi.org/10.14233/ajchem.2025.34249
Sadia Sultana
Department of Chemistry, Chittagong University of Engineering and Technology, Chattogram-4349, Bangladesh
https://orcid.org/0009-0009-4410-0285
Priya Barua
Department of Chemistry, Chittagong University of Engineering and Technology, Chattogram-4349, Bangladesh
https://orcid.org/0009-0001-7505-0331
Md. Din Islam
Department of Chemistry, Chittagong University of Engineering and Technology, Chattogram-4349, Bangladesh
https://orcid.org/0000-0003-4652-8081
Ranajit Kumar Sutradhar
Department of Chemistry, Chittagong University of Engineering and Technology, Chattogram-4349, Bangladesh
https://orcid.org/0000-0002-6020-0528

Corresponding Author(s) : Ranajit Kumar Sutradhar

rksutradhar2002@yahoo.com

Asian Journal of Chemistry, Vol. 37 No. 9 (2025): Vol 37 Issue 9, 2025

Abstract

Thiazole, a heterocyclic compound containing Schiff bases being a compound’s core can enhance the drug potency. This study contributes to the synthesis of three novel thiazole Schiff base derivatives 2a-c by two-step synthesis method. The structures of the synthesized compounds were established by spectral analysis. Antimicrobial and antioxidant screening of synthesized compounds showed moderate to significant antimicrobial and antioxidant activities. Compounds 2c showed excellent antimicrobial and antioxidant activities. The synthesized analogs showed good binding affinity and a variety of strong interactions with the effective binding sites of the target receptors. In silico studies support the antimicrobial results very well. It is expected that the synthesized analogs have a good drug score and contribute to the development of a more potent drug in the future.

Keywords

Synthesis Thiazole Bioactivity In silico study ADME prediction
(1)
Sultana, S.; Barua, P.; Islam, M. D.; Sutradhar, R. K. Synthesis, Bioactivity Screening and in Silico Studies of Phenyl Thiazole Derivatives Containing Arylidene Moieties. ajc 2025, 37, 2202-2210.
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