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Vol. 31 No. 9 (2019): Vol 31 Issue 9

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DNA Binding Properties and Antibacterial Activity of Heterolyptic Transition Metal Complexes with 2,2-Bipyridyl and 2-Acetylthiophene Thiosemicarbazone

https://doi.org/10.14233/ajchem.2019.22018
Kummara Srinivasulu
Department of Chemistry, Sri Krishnadevraya University, Ananthapuramu-515003, India
Katreddi Hussain Reddy
Department of Chemistry, Sri Krishnadevraya University, Ananthapuramu-515003, India
K. Anuja
Department of Chemistry, Sri Krishnadevraya University, Ananthapuramu-515003, India
D. Dhanalakshmi
Department of Chemistry, Sri Krishnadevraya University, Ananthapuramu-515003, India
Golla Ramesh
Department of Studies and Research in Chemistry, University College of Science, Tumkur University, Tumkur-572103, India

Corresponding Author(s) : Katreddi Hussain Reddy

khussainreddy@yahoo.co.in

Asian Journal of Chemistry, Vol. 31 No. 9 (2019): Vol 31 Issue 9

Abstract

Metal complexes having the composition M(Bipy)Cl2 (where, M = Cu(II), Ni(II) and Co(II); Bipy = 2,2-bipyridyl) are reacted with 2-acetylthiophene thiosemicarbazone (ATT) to produce heteroleptic transition metal complexes with molecular formula [M(Bipy)ATT]. The complexes are characterized by mass spectra, molar conductivity, infrared and electronic spectra. Electrochemical behaviour of these metal complexes was investigated by cyclic voltammetric studies. The metal complexes show quasi reversible cyclic voltammetric responses for the Cu(II)/Cu(I) couple. The binding properties of these complexes with calf-thymus DNA have been investigated by using absorption spectrophotometry. Metal complexes are screened for their antibacterial activity by using agar well diffusion method against pathogenic bacterial strains viz. Escherichia coli and Staphylococcus aureus. Antibacterial activity of the present complexes are comparable with the activity of ciprofloxacin. The Cu(Bipy)Cl2 complex inhibits bacteria more strongly than any other complex. The Ni(Bipy)ATT complex shows more activity than the parent complex, Ni(Bipy)Cl2.

Keywords

Heterolyptic transition metal complexes 2,2-Bipyridyl ATT DNA binding Antibacterial activity
Srinivasulu, K., Reddy, K. H., Anuja, K., Dhanalakshmi, D., & Ramesh, G. (2019). DNA Binding Properties and Antibacterial Activity of Heterolyptic Transition Metal Complexes with 2,2-Bipyridyl and 2-Acetylthiophene Thiosemicarbazone. Asian Journal of Chemistry, 31(9), 1905–1912. https://doi.org/10.14233/ajchem.2019.22018
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