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Vol. 26 No. 19 (2014): Vol 26 Issue 19

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Preparation and Characterization of Aqueous Bifunctional Fe3O4/CdSe/CdS Nanocomposites and Its Application in Immunolabelling of Cancer Cells

https://doi.org/10.14233/ajchem.2014.16483
Dongzhi Yang
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, P.R. China
Shian Sun
Xuzhou Air Force College, Xuzhou 221000, Jiangsu Province, P.R. China
Yan Du
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, P.R. China
Junnian Zheng
Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, P.R. China

Corresponding Author(s) : Junnian Zheng

yaowufenxi_xzmc@163.com

Asian Journal of Chemistry, Vol. 26 No. 19 (2014): Vol 26 Issue 19

Abstract

A novel method to prepare aqueous magnetic and luminescent Fe3O4/CdSe/CdS nanocomposites was demonstrated. Fe3O4 magnetic nanoparticles were first synthesized by a chemical coprecipitation method with PEG4000 as stabilizer. After being modified by citric acid, the Fe3O4-COOH magnetic nanoparticles were coated with silica shells by Stober method, followed by modification with thiol groups through the sol-gel method. The surface-modified Fe3O4 nanoparticles were lastly linked to CdSe/CdS quantum dots, which were synthesized in aqueous solution with thioglycolic acid as stabilizer, to form Fe3O4/CdSe/CdS bifunctional nanocomposites through coordination. Their optical and structural properties were characterized by photoluminescence, vibrating sample magnetometer and X-ray diffraction studies. It was indicted that the water soluble nanocomposites possess both the magnetic and photoluminescence properties. It was used as fluorescent label in detection of carcinoembryonic antigen, a cancer marker expressed on the surface of HeLa cells. The present study demonstrates the practicability of the prepared nanocomposites as an attractive type of fluorescent labels for biological applications.

Keywords

Fe3O4/CdSe/CdS nanocomposites Quantum dots Magnetic nanoparticles Cell imaging
Yang, D., Sun, S., Du, Y., & Zheng, J. (2014). Preparation and Characterization of Aqueous Bifunctional Fe3O4/CdSe/CdS Nanocomposites and Its Application in Immunolabelling of Cancer Cells. Asian Journal of Chemistry, 26(19), 6531–6534. https://doi.org/10.14233/ajchem.2014.16483
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