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Vol. 26 No. 19 (2014): Vol 26 Issue 19

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γ-Fe2O3@Polyaniline-Chlorambucil Synthesized by Using Doping/Dedoping Method of Polyaniline

https://doi.org/10.14233/ajchem.2014.16474
Qian Shen
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P.R. China
Jianping Lang
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P.R. China
Jinqing Kan
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P.R. China

Corresponding Author(s) : Jinqing Kan

jqkan@yzu.edu.cn

Asian Journal of Chemistry, Vol. 26 No. 19 (2014): Vol 26 Issue 19

Abstract

The g-Fe2O3@polyaniline-chlorambucil composite has been synthesized. The g-Fe2O3@PANI is modified by chlorambucil (CHB, a chemotherapeutic drug) based on the unique doping-dedoping mechanism of the polyaniline, which don't change doped groups of the chlorambucil. It is confirmed by XRD, VSM, FT-IR and TEM that the chlorambucil was doped into g-Fe2O3@PANI. The experimental results showed that the g-Fe2O3@PANI-CHB has the superparamagnet, electrochemical activity and good conductivity. The poly(vinyl, pyrrolidone) surfactant could improve the suspensibility of g-Fe2O3@PANI-CHB in the aqueous solution. The g-Fe2O3@PANI-CHB could be concentrated in a magnetic field. The concentration of the g-Fe2O3@PANI-CHB at 3000 Gauss was 6 times higher than that of the original solution at a flow rate of 0.1118 g s-1. The results showed that g-Fe2O3@PANI-CHB can kill Madin Darby Canine Kidney (MDCK) but there is no toxic effect of g-Fe2O3@PANI on Madin Darby Canine Kidney cells.

Keywords

Polyaniline Chlorambucil Superparamagnetism Nano-composite γ-Fe2O3
Shen, Q., Lang, J., & Kan, J. (2014). γ-Fe2O3@Polyaniline-Chlorambucil Synthesized by Using Doping/Dedoping Method of Polyaniline. Asian Journal of Chemistry, 26(19), 6492–6498. https://doi.org/10.14233/ajchem.2014.16474
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