Synthesis of Manganese Complexes of 4,5-Dihydropyrazoles and Metalation Effect on the Antimicrobial Activity

Mamta Ahuja

doi:10.14233/ajchem.2014.16428

Issue

Vol. 26 No. 19 (2014): Vol 26 Issue 19

Issue Published : September 16, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis of Manganese Complexes of 4,5-Dihydropyrazoles and Metalation Effect on the Antimicrobial Activity

https://doi.org/10.14233/ajchem.2014.16428

Mamta Ahuja

Department of Chemistry, Government Meera Girls College, Mohan Lal Sukhadia University, Udaipur-313 001, India

Corresponding Author(s) : Mamta Ahuja

mamdeep@rediffmail.com

Asian Journal of Chemistry, Vol. 26 No. 19 (2014): Vol 26 Issue 19
Article Published : September 18, 2014

Abstract

1-Acetyl-5-aryl-3-(substituted thienyl)-4,5-dihydropyrazoles and their manganese complexes have been synthesized and characterized on the basis of elemental analysis, magnetic susceptibility, molar conductance, molecular weight determination and spectroscopic data. The IR data indicated that the coordination of the ligands to the manganese (II) ion was through the azomethine nitrogen and carbonyl oxygen. The micro analytical, electronic spectral assignments and magnetic moment suggested an octahedral geometry around the metal ion with 1:2 metal ligand stoichiometry. The complexes exhibited in vitro microbiocidal activity in comparison to ligands.

Keywords

Dihydropyrazoles Manganese Complexes Microbiocidal activity. Microbiocidal activity

Ahuja, M. (2014). Synthesis of Manganese Complexes of 4,5-Dihydropyrazoles and Metalation Effect on the Antimicrobial Activity. Asian Journal of Chemistry, 26(19), 6443–6446. https://doi.org/10.14233/ajchem.2014.16428

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References

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References

P.-C. Lv, H.-Q. Li, J. Sun, Y. Zhou and H.-L. Zhu, Bioorg. Med. Chem., 18, 4606 (2010); doi:10.1016/j.bmc.2010.05.034.

M.S. Christodoulou, S. Liekens, K.M. Kasiotis and S.A. Haroutounian, Bioorg. Med. Chem., 18, 4338 (2010); doi:10.1016/j.bmc.2010.04.076.

B.F. Abdel-Wahab, H.A. Abdel-Aziz and E.M. Ahmed, Eur. J. Med. Chem., 44, 2632 (2009); doi:10.1016/j.ejmech.2008.09.029.

D. Zampieri, M.G. Mamolo, E. Laurini, G. Scialino, E. Banfi and L. Vio, Bioorg. Med. Chem., 16, 4516 (2008); doi:10.1016/j.bmc.2008.02.055.

O.L. El-Sabbagh, M.M. Baraka, S.M. Ibrahim, P. Pannecouque, G. Andrei, R. Snoeck, J. Balzarini and A.A. Rashad, Eur. J. Med. Chem., 44, 3746 (2009); doi:10.1016/j.ejmech.2009.03.038.

M.S. Karthikeyan, B.S. Holla and N.S. Kumari, Eur. J. Med. Chem., 42, 30 (2007); doi:10.1016/j.ejmech.2006.07.011.

B.F. Abdel-Wahab, H.A. Abdel-Aziz and E.M. Ahmed, Eur. J. Med. Chem., 44, 2632 (2009); doi:10.1016/j.ejmech.2008.09.029.

M. Abdel-Aziz, A. El-Din, G. Abuo-Rahma and A. A. Hassan, Eur. J. Med. Chem., 44, 3480 (2009); doi:10.1016/j.ejmech.2009.01.032.

N. Gokhan-Kelekc, S. Yabanoglu, E. Ku Peli, U. Salgm, O. Ozgen, G. Ucar, E. Yesilada, E. Kendi, Y. Yesiladaf and A.A. Bilgin, Bioorg. Med. Chem., 15, 5775 (2007); doi:10.1016/j.bmc.2007.06.004.

R. Malhotra, M.S. Malik, J.P. Singh and K.S. Dhindsa, J. Inorg. Biochem., 45, 269 (1992); doi:10.1016/0162-0134(92)84015-F.

R. Malhotra, J.P. Singh, M. Dudeja and K.S. Dhindsa, J. Inorg. Biochem., 46, 119 (1992); doi:10.1016/0162-0134(92)80015-N.

P. Lumme, H. Elo and J. Janne, Inorg. Chim. Acta, 92, 241 (1984); doi:10.1016/S0020-1693(00)80045-6.

R. Malhotra, S. Kumar and K.S. Dhindsa, Indian J. Chem., 32A, 457, (1993).

N.K. Sangwan, B.S. Verma and K.S. Dhindsa, J. Prakt. Chem., 330, 137 (1988); doi:10.1002/prac.19883300125.

N.R. El-Rayyes and N.A. Al-Awadi, Synthesis, 1028 (1985); doi:10.1055/s-1985-31422.

N.K. Sangwan, B.S. Verma and K.S. Dhindsa, Indian J. Chem., 25B, 672 (1986).

R.C. Sharma and R.K. Parashar, J. Inorg. Biochem., 32, 163 (1988); doi:10.1016/0162-0134(88)80024-2.

L.J. Heidt, G.F. Koster and A.M. Johnson, J. Am. Chem. Soc., 80, 6471 (1958); doi:10.1021/ja01557a001.

R. Nagar, J. Inorg. Biochem., 37, 193 (1989); doi:10.1016/0162-0134(89)80042-X.K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compound, Wiley Interscience, New York (1978).

G.C. Donald and A.R. Williams, A Laboratory Manual, Medical Encyclopedia Inc (1955).

V.F. Portyanko, A.P. Myagchenko and V.I. Dulova, Fiziol. Biokhim. Kul’t. Rast., 14, 371 (1982).

M. Windholz, The Merck Index, Merck & Co., New Jersey, edn 9 (1976).

H. Theorell, T. Yonetani, B. Sjoberg, O. Theander, A.A. Lindberg, G. Jansen, B. Lamm and B. Samuelsson, Acta Chem. Scand., 23, 255 (1969); doi:10.3891/acta.chem.scand.23-0255.

Issue

Vol. 26 No. 19 (2014): Vol 26 Issue 19

Synthesis of Manganese Complexes of 4,5-Dihydropyrazoles and Metalation Effect on the Antimicrobial Activity

Corresponding Author(s) : Mamta Ahuja

Abstract

Keywords

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