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Vol. 38 No. 9 (2026): Vol 38 Issue 9 Year 2026

Copyright (c) 2026 RUTUJA PALASKAR, KAPIL SHINDE, DARSHANA DHOKANE, MANSINGHRAJ NIMBALKAR, AMRUTA BELHEKAR, Umesh Jadhav

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Barleria acuminata Extract-Mediated Organic–Inorganic Copper Phosphate Nanohybrids: Synthesis, Optimization and Antioxidant Potential

https://doi.org/10.14233/ajchem.2026.36490
R. Palaskar
Department of Microbiology, Savitribai Phule Pune University, Pune-411007, India
https://orcid.org/0000-0002-5281-6744
K. Shinde
Department of Biotechnology, Shivaji University, Kolhapur-416004, India
https://orcid.org/0000-0001-6508-2279
D. Dhokane
Department of Microbiology, Savitribai Phule Pune University, Pune-411007, India
https://orcid.org/0009-0004-5771-6664
M. Nimbalkar
Department of Botany, Shivaji University, Kolhapur-416004, India
https://orcid.org/0000-0002-9238-5491
A. Belhekar
Department of Chemistry, Savitribai Phule Pune University, Pune-411007, India
https://orcid.org/0009-0000-0178-8379
U. Jadhav
Department of Microbiology, Savitribai Phule Pune University, Pune-411007, India
https://orcid.org/0000-0001-8144-6431

Corresponding Author(s) : U. Jadhav

umeshjadhav02@gmail.com

Asian Journal of Chemistry, Vol. 38 No. 9 (2026): Vol 38 Issue 9 Year 2026

Abstract

In the present study, we report the green synthesis of Barleria acuminata extract mediated copper phosphate nanohybrids (BAE-CuPNHs) by a simple one-pot co-precipitation approach. Aqueous extracts of six different Barleria species were prepared by using ultrasonication and microwave-assisted extraction methods and evaluated for total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activity. Among the tested species, B. acuminata showed highest phytochemical content and DPPH radical scavenging activity and was selected for nanohybrid preparation. The formation of nanohybrid was screened for different metal ions. Copper ions formed well-defined flower-like nanostructures with high efficiency of phytochemical immobilization. Optimization studies showed 4 mM CuSO4, 2.0 mL PBS, static incubation and an incubation period of 72 h as the optimum conditions for the synthesis. FESEM, EDX, FTIR and XRD characterization confirmed the formation of crystalline BAE-CuPNHs with marigold-like morphology. The synthesized BAE-CuPNHs displayed antioxidant activity, indicating their promising prospects for antioxidant delivery and bioactive applications.

Keywords

Barleria acuminata Organic-inorganic nanohybrid Phytochemical immobilization Antioxidant activity
(1)
Palaskar, R.; Shinde, K.; Dhokane, D.; Nimbalkar, M.; Belhekar, A.; Jadhav, U. Barleria Acuminata Extract-Mediated Organic–Inorganic Copper Phosphate Nanohybrids: Synthesis, Optimization and Antioxidant Potential. ajc 2026, 38, 2427-2437.
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