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Vol. 38 No. 8 (2026): Vol 38, Issue 8 (2026)

Copyright (c) 2026 KRISHNA MOORTHY C

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Green Synthesis, Bioevaluation and Molecular Docking Studies of a Novel Sulphone-Derived Schiff Base Ligand and its Metal(II) Complexes

https://doi.org/10.14233/ajchem.2026.36504
C. Krishna Moorthy
Department of Chemistry, Kangeyam Institute of Technology, Kangeyam, Tirupur-638108, India
https://orcid.org/0009-0002-3717-9131
T. Gomathi
Department of Chemistry, Paavai College of Engineering, Namakkal-637018, India
https://orcid.org/0000-0002-4700-9227
M. Kannan
Department of Bioinformatics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-602105, India
https://orcid.org/0000-0002-9250-2379
T. Mohanapriya
Department of Chemistry, Erode Arts and Science College (Autonomous), Erode-638009, India
https://orcid.org/0009-0008-0076-2343

Corresponding Author(s) : T. Mohanapriya

mohanapriyat239@gmail.com

Asian Journal of Chemistry, Vol. 38 No. 8 (2026): Vol 38, Issue 8 (2026)

Abstract

A Schiff base ligand was synthesised via the condensation reaction of 4,4'-sulfonyldianiline and furfuraldehyde using cashew nut shell liquid (CNSL)-derived anacardic acid, which served as an environmentally benign and naturally efficient catalyst under solvent-free conditions. The resulting Schiff base was subsequently reacted with Co(II), Ni(II), Cu(II) and Zn(II) acetate precursors to produce the corresponding metal complexes. The widespread utilisation of organic solvents poses a significant environmental concern because of the generation of hazardous byproducts. The increasing focus on sustainable synthetic methodologies has accelerated the use of solvent-free green catalytic systems as an attractive alternative to conventional protocols. These methods reduce solvent usage, limit waste generation and improve process sustainability. The structural and coordination characteristics of the synthesised ligand and its metal complexes were established using UV-Visible, FT-IR, 1H NMR, 13C NMR, mass spectrometry and scanning electron microscopy (SEM). The synthesized ligand and its metal complexes were evaluated for antimicrobial activity against E. coli, S. aureus and C. albicans using the agar well diffusion method. The tested compounds exhibited appreciable antimicrobial activity against the selected microorganisms. The Schiff base ligand and its Cu(II) complex were further assessed for cytotoxicity against the MCF-7 human breast cancer cell line using the MTT assay. Molecular docking of the Cu(II) complex with the HER2 receptor revealed favourable binding interactions, supporting its potential biological significance.

Keywords

Cashew nut shell liquid (CNSL) MCF-7 Molecular docking Ligand–protein
(1)
Moorthy, C. K.; Gomathi, T.; Kannan, M.; Mohanapriya, T. Green Synthesis, Bioevaluation and Molecular Docking Studies of a Novel Sulphone-Derived Schiff Base Ligand and Its Metal(II) Complexes. ajc 2026, 38, 2215-2224.
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