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Vol. 38 No. 8 (2026): Vol 38, Issue 8 (2026)

Copyright (c) 2026 Tapashi Ghosh Roy Tapashi

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Bioactive Azamacrocyclic Zinc(II) Complexes: Synthesis and Characterisation

https://doi.org/10.14233/ajchem.2026.36377
Tumpa Rani Majumder
Department of Chemistry, University of Chittagong, Chattogram-4331, Bangladesh
https://orcid.org/0009-0000-3364-1718
Pradip Paul
Department of Chemistry, University of Chittagong, Chattogram-4331, Bangladesh
https://orcid.org/0000-0001-5408-8667
Saswata Rabi
Department of Chemistry, Chittagong University of Engineering & Technology, Chattogram-4349, Bangladesh
https://orcid.org/0000-0001-5911-1184
Avijit Chakraborty
Department of Chemistry, University of Chittagong, Chattogram-4331, Bangladesh
https://orcid.org/0000-0002-7860-8273
Foni Bushon Biswas
Department of Chemistry, University of Chittagong, Chattogram-4331, Bangladesh
https://orcid.org/0000-0002-0935-8530
Debashis Palit
Department of Chemistry, University of Chittagong, Chattogram-4331, Bangladesh
https://orcid.org/0000-0002-4253-0232
Tapashi Ghosh Roy
Department of Chemistry, University of Chittagong, Chattogram-4331, Bangladesh
https://orcid.org/0000-0002-2192-1584

Corresponding Author(s) : Tapashi Ghosh Roy

tapashir57@cu.ac.bd

Asian Journal of Chemistry, Vol. 38 No. 8 (2026): Vol 38, Issue 8 (2026)

Abstract

Reduction of Me8[14]diene·2HClO4 (L·2HClO4) afforded three isomeric ligands (LA, LB and LC), among which LC underwent cyanoethylation with excess acrylonitrile to form the bis-cyanoethyl derivative (LCX). Reaction of LCX with zinc(II) chloride yielded the six-coordinate complex [Zn(LCX)Cl2], which subsequently underwent axial ligand substitution with KSCN, KNO3, NaNO2, KBr and KI to produce a series of octahedral zinc(II) complexes, [Zn(LCX)(X)2] (X = NCS, NO3, NO2, Br or I). All the Zn(II) synthesised complexes were characterized using various analytical and spectroscopic techniques. Their antibacterial activity was evaluated against four selected bacterial strains and most of the complexes exhibited good antibacterial activity against the tested bacteria.

Keywords

Tetraazamacrocyclic ligand Cyanoethyl derivative Zinc(II) complexes Antibacterial studies
(1)
Majumder, T. R.; Paul, P.; Rabi, S.; Chakraborty, A.; Biswas, F. B.; Palit, D.; Roy, T. G. Bioactive Azamacrocyclic Zinc(II) Complexes: Synthesis and Characterisation. ajc 2026, 38, 2146-2150.
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