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Vol. 38 No. 8 (2026): Vol 38, Issue 8 (2026)

Copyright (c) 2026 P. Lydia Festus Kanmani, S. Durga Devi, Palanisamy Karumalaiyan, A. Leema Rose

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Grindstone Assisted Synthesis of Pyrimido-Xanthene Analogues and its Antioxidant, Antidiabetic and Docking Studies

https://doi.org/10.14233/ajchem.2026.36319
P. Lydia Festus Kanmani
Research Department of Chemistry, Holy Cross College (Affiliated to Bharathidasan University), Tiruchirappalli-620002, India
https://orcid.org/0000-0001-7203-9121
S. Durga Devi
Research Department of Chemistry, Holy Cross College (Affiliated to Bharathidasan University), Tiruchirappalli-620002, India
https://orcid.org/0000-0003-2799-9953
K. Palanisamy
Research Department of Chemistry, Thanthai Hans Roever College (Affiliated to Bharathidasan University), Perambalur-621220, India
https://orcid.org/0000-0002-4745-8583
A. Leema Rose
Research Department of Chemistry, Holy Cross College (Affiliated to Bharathidasan University), Tiruchirappalli-620002, India
https://orcid.org/0000-0001-9978-2118

Corresponding Author(s) : A. Leema Rose

leemarose25@gmail.com

Asian Journal of Chemistry, Vol. 38 No. 8 (2026): Vol 38, Issue 8 (2026)

Abstract

The present study aimed to synthesise a series of pyrimido-xanthene analogues via the Biginelli reaction using an eco-friendly grindstone approach and FeSO4·7H2O as an efficient catalyst. The synthesised compounds were characterized by elemental analysis, FT-IR, 1H and 13C NMR spectroscopy, and HR-MS. The newly synthesised analogues (2a-j) were subsequently evaluated for their antioxidant and antidiabetic activities. Among the tested compounds, analogue 2b exhibited the most promising antioxidant and antidiabetic potential. Furthermore, molecular docking studies were also performed to gain insights into the binding interactions and inhibition mechanism of the title compounds against the target enzymes.

Keywords

Antidiabetic Antioxidant Grindstone Molecular docking Pyrimidine Xanthene
(1)
Kanmani, P. L. F.; Devi, S. D.; Palanisamy, K.; Rose, A. L. Grindstone Assisted Synthesis of Pyrimido-Xanthene Analogues and Its Antioxidant, Antidiabetic and Docking Studies. ajc 2026, 38, 2089-2101.
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