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Vol. 38 No. 7 (2026): Vol. 38, No 7 (2026)

Copyright (c) 2026 K.Subashini -, Chitra G, Ramkumar.P, Guhanathan. S

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Physico-chemical Characterisation and Biomedical Applications of Diols and Citric Acid based Indole-3-Acetic Acid Polyester Hydrogels

https://doi.org/10.14233/ajchem.2026.35811
G. Chitra
Department of Chemistry, Government Polytechnic College, Kelamangalam, Krishnagiri-635113, India
https://orcid.org/0000-0002-9981-0753
S. Guhanathan
Department of Chemistry, Muthurangam Government Arts College (Affiliated to Thiruvalluvar University, Serkadu), Vellore-632002, India
https://orcid.org/0000-0002-8986-1637
K. Subashini
Department of Chemistry, Applied Sciences, New Horizon College of Engineering, Bangalore-560103, India
https://orcid.org/0000-0001-6842-7199
P. Ramkumar
Department of Computer Science and Engineering, Sri Sairam College of Engineering, Bangalore-562106, India
https://orcid.org/0000-0001-6635-6550

Corresponding Author(s) : G. Chitra

chitramuralikrishnan@gmail.com

Asian Journal of Chemistry, Vol. 38 No. 7 (2026): Vol. 38, No 7 (2026)

Abstract

In this work, indole-3-acetic acid (IAA)-based polyester hydrogels were synthesized using citric acid and three different diols, namely ethylene glycol, diethylene glycol and triethylene glycol, to obtain ICAE, ICAD and ICAT hydrogels. The synthesized hydrogels were characterized by FT-IR, 1H NMR, SEM, TGA and swelling studies, confirming successful hydrogel formation and structural integrity. All hydrogels exhibited pH-dependent swelling behaviour, with ICAE showing the highest swelling equilibrium (1600% at pH 3). Biological evaluation revealed concentration-dependent antifungal activity, excellent biocompatibility with cell viability above 80% and significant wound-healing potential. Among the formulations, ICAE demonstrated superior antifungal efficacy, 75% wound closure after 72 h and the strongest anticancer activity against A549 cells with an IC50 value of 138 µg/mL. The enhanced performance of ICAE was attributed to its higher swelling capacity and favourable biological properties. These results suggest that ICAE is a promising multi-functional hydrogel for wound management and anticancer biomedical applications.

Keywords

Heterocyclic hydrogel Diols Wound healing FT-IR Anticancer activities
(1)
Chitra, G.; Guhanathan, S.; Subashini, K.; Ramkumar, P. Synthesis, Physico-Chemical Characterisation and Biomedical Applications of Diols and Citric Acid Based Indole-3-Acetic Acid Polyester Hydrogels. ajc 2026, 38, 1921-1929.
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