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Vol. 38 No. 7 (2026): Vol. 38, No 7 (2026)

Copyright (c) 2026 Moodu Nagu M NAGU

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Synthesis, Characterisation, Cytotoxicity, Antimicrobial and Docking Studies of (2,4-Bis((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)(phenyl)methanone Derivatives

https://doi.org/10.14233/ajchem.2026.36100
Moodu Nagu
Department of Chemistry, Nagarjuna Government College (Autonomous) (Affiliated to Mahatma Gandhi University), Nalgonda-508001, India
https://orcid.org/0009-0006-9120-5918
Bolisetti Venkateswarlu
Department of Chemistry, Nagarjuna Government College (Autonomous) (Affiliated to Mahatma Gandhi University), Nalgonda-508001, India
https://orcid.org/0009-0009-2360-8653

Corresponding Author(s) : Bolisetti Venkateswarlu

venkateswarlu.bolisetty@gmail.com

Asian Journal of Chemistry, Vol. 38 No. 7 (2026): Vol. 38, No 7 (2026)

Abstract

Using a copper(I)-catalysed azide-alkyne (CuAAC) cycloaddition method, a new series of 2,4-bis((1-phenyl-1H-1,2,3-triazol-4-yl)-methoxy)phenyl)(phenyl)methanone analogues (7a-o) were synthesised, characterised by 1H and 13C NMR, FT-IR, mass and elemental analysis and evaluated for the biological activities. Cell viability method on MCF-7, HeLa and PC-3 cells revealed compounds 7d, 7j and 7f exhibited potent cytotoxicity, while other compounds displayed moderate to weak effects, indicating promising anticancer potential for selected derivatives. Antibacterial and antifungal activities were tested using disc diffusion method, among the tested compounds 7d, 7f and 7k showed strong activity, outperforming streptomycin and amphotericin B. Molecular docking against 17β-HSD1 demonstrated high binding affinities for 7j (-12.4 kcal/mol) and 7d (-12.3 kcal/mol), superior to doxorubicin (-8.9 kcal/mol), forming interactions with key residues like ILE14 and SER142. These findings suggest the synthesised compounds are promising anticancer and antimicrobial agents.

Keywords

CuAAC reaction 1,2,3-Triazole hybrids Anticancer agents Antifungal evaluation VEGFR2 inhibition
(1)
Nagu, M.; Venkateswarlu, B. Synthesis, Characterisation, Cytotoxicity, Antimicrobial and Docking Studies of (2,4-Bis(1-Phenyl-1H-1,2,3-Triazol-4-yl)methoxy)phenyl)(phenyl)methanone Derivatives. ajc 2026, 38, 1795-1804.
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